Department of Radiology, Hospital Sirio-Libanes, Sao Paulo, Brazil.
Department of Radiology and Oncology, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil.
PET Clin. 2021 Jul;16(3):313-326. doi: 10.1016/j.cpet.2021.03.010.
Theranostics describes the pairing of diagnostic biomarkers and therapeutic agents with common specific targets. Nuclear medicine is the greatest theranostics protagonist, relying on radioactive tracers for imaging biologic phenomena and delivering ionizing radiation to the tissues that take up those tracers. The concept has gained importance with the growth of personalized medicine, allowing customized management for diseases, refining patient selection, better predicting responses, reducing toxicity, and estimating prognosis. This work provides an overview of the general concepts of the theranostics approach in nuclear medicine discussing its background, features, and future directions in imaging and therapy.
治疗诊断学描述了将诊断生物标志物和治疗剂与常见的特定靶标配对。核医学是最大的治疗诊断学主角，依靠放射性示踪剂来成像生物现象，并将电离辐射递送到摄取这些示踪剂的组织。随着个性化医学的发展，该概念变得越来越重要，它允许针对疾病进行定制化管理，完善患者选择，更好地预测反应，降低毒性并估计预后。本文综述了核医学中治疗诊断方法的一般概念，讨论了其在成像和治疗方面的背景、特点和未来方向。
