Department of Molecular Imaging and Radionuclide Therapy (MIRT), The Persian Gulf Nuclear Medicine Research Center, Bushehr Medical University Hospital, School of Medicine, Bushehr University of Medical Sciences, Bushehr, Iran.
Department of Nuclear Medicine, University Hospital Bonn, Bonn, Germany; Department of Radiology, Marienhospital Bonn, Bonn, Germany.
PET Clin. 2021 Jul;16(3):429-440. doi: 10.1016/j.cpet.2021.03.009.
Studies in nuclear medicine have shed light on molecular imaging and therapeutic approaches for oncological and nononcological conditions. Using the same radiopharmaceuticals for diagnosis and therapeutics of malignancies, the theranostics approach, has improved clinical management of patients. Theranostic approaches for nononcological conditions are recognized as emerging topics of research. This review focuses on preclinical and clinical studies of nononcological disorders that include theranostic strategies. Theranostic approaches are demonstrated as possible in the clinical management of infections and inflammations. There is an emerging need for randomized trials to specify the factors affecting validity and efficacy of theranostic approaches in nononcological diseases.
核医学研究为肿瘤和非肿瘤疾病的分子影像和治疗方法提供了新的视角。利用相同的放射性药物进行恶性肿瘤的诊断和治疗，即治疗诊断学方法，改善了患者的临床管理。非肿瘤疾病的治疗诊断方法被认为是新兴的研究课题。本综述重点介绍了包括治疗诊断策略在内的非肿瘤性疾病的临床前和临床研究。治疗诊断方法在感染和炎症的临床治疗中显示出了一定的可行性。目前迫切需要进行随机试验来明确影响非肿瘤性疾病治疗诊断方法有效性和疗效的因素。
