Labbafinejad Clinical Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Infectious Diseases and Tropical Medicine Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Infect Disord Drug Targets. 2021;21(1):142-145. doi: 10.2174/1871526520666200218115400.
CDATA[Introduction: Epididymo-orchitis is a common urological disease among men. Little is known about the clinical and epidemiological aspects of the disease in Iran. Thus, the present study was aimed at investigating the etiology, clinical sequelae and risk factors of patients with epididymo- orchitis in Tehran, Iran.
Patients presenting with epididymo-orchitis were prospectively analyzed in order to study the etiology and pattern of the disease. Bacteriological, molecular and serological tests were undertaken to look for Chlamydia trachomatis, Neisseria gonorrhoeae, Brucella spp., Mycoplasma spp, and other bacteria.
Fifty patients with epididymo-orchitis were evaluated according to their clinical symptoms, duration of symptoms, physical examination, and laboratory studies. The mean age of the patients was 53 years. Fever, dysuria, pain in the flanks, urinary frequency and discharges occurred in 58.0%, 50.0%, 50.0%, 28.0% and 6.0%, respectively. Bacterial pathogen was identified in 26% (13/50) of patients by urine culture. Escherichia coli was the etiological agent in 11/13 patients (84.6%). Two out of 50 patients (4.0%) were also positive for Chlamydia trachomatis. Two samples were serologically positive for Brucella spp. High Mean age, fever, urinary frequency, history of the underlying disease and history of urinary tract infections were found to have a significant association with the positive bacteriologic urine culture (P<0.05).
The most common clinical manifestations were fever, dysuria, and abdominal pain. E. coli and C. trachomatis were the major causative agents. The use of a set of diagnostic approaches including clinical symptoms, urine culture and more precise techniques such as PCR should be taken into consideration for the definitive diagnosis.
介绍 背景：附睾炎是男性常见的泌尿系统疾病。然而，有关伊朗该病的临床和流行病学方面的信息知之甚少。因此，本研究旨在调查伊朗德黑兰地区附睾炎患者的病因、临床后果和危险因素。
前瞻性分析附睾炎患者，以研究该病的病因和发病模式。进行细菌学、分子学和血清学检查，以寻找沙眼衣原体、淋病奈瑟菌、布鲁氏菌属、支原体属和其他细菌。
根据临床症状、症状持续时间、体格检查和实验室研究，评估了 50 例附睾炎患者。患者的平均年龄为 53 岁。58.0%、50.0%、50.0%、28.0%和 6.0%的患者分别出现发热、尿痛、腰部疼痛、尿频和分泌物。通过尿液培养，26%（13/50）的患者确定了细菌病原体。11/13 名患者（84.6%）的病原体为大肠杆菌。50 名患者中有 2 名（4.0%）也对沙眼衣原体呈阳性。2 份标本血清学检测布鲁氏菌属呈阳性。高年龄、发热、尿频、潜在疾病史和尿路感染史与阳性细菌尿培养有显著相关性（P<0.05）。
最常见的临床表现为发热、尿痛和腹痛。大肠杆菌和沙眼衣原体是主要的病原体。应考虑采用包括临床症状、尿液培养在内的一系列诊断方法，以及更精确的技术如 PCR，以明确诊断。
