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免疫功能正常患者的附睾炎-睾丸炎与菌血症

Epididymo-Orchitis and Bacteraemia in an Immunocompetent Patient.

作者信息

Farouji Abdelhadi, Haddad Ahmad W, Khan Nibras Yar, Battah Arwa, Ahmad Amaar S, Slim Jihad

机构信息

Department of Internal Medicine, Saint Michael's Medical Center, New York Medical College, Newark, USA.

Department of Infectious Diseases, Saint Michael's Medical Center, New York Medical College, Newark, USA.

出版信息

Eur J Case Rep Intern Med. 2023 Dec 15;11(1):004205. doi: 10.12890/2023_004205. eCollection 2024.

DOI:10.12890/2023_004205
PMID:38223271
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10783462/
Abstract

BACKGROUND

Epididymitis is a common cause of scrotal pain in adults, with coliform bacteria being the most common isolated organisms in patients older than 35.

CASE PRESENTATION

A 51-year-old healthy patient presented with scrotal pain and swelling, and was found to have epididymo-orchitis and bacteraemia caused by , which has not previously been reported as a cause of epididymo-orchitis and bacteraemia in immunocompetent patients.

DISCUSSION

Diagnostic studies can help confirm the diagnosis and detect the causative pathogen. In all suspected cases, a urinalysis, urine culture and a urine or urethral swab for nucleic acid amplification tests (NAATs) for and should be performed. Colour Doppler ultrasonography often shows an enlarged thickened epididymis with increased Doppler wave pulsation in epididymitis. are pleomorphic gram-negative rods that commonly colonise the human respiratory tract and are associated with a number of clinical conditions. has been reported as a cause of epididymo-orchitis in prepubertal boys, and in few cases were associated with positive blood cultures. In adults, has been isolated before from urine samples or urethral swabs in patients with epididymitis or epididymo-orchitis.

CONCLUSION

This case highlights the possibility of causing epididymo-orchitis and bacteraemia in immunocompetent patients. Healthcare providers should consider in the differential diagnosis of epididymitis and epididymo-orchitis in both immunocompetent and immunocompromised patients.

LEARNING POINTS

can cause epididymo-orchitis and bacteraemia in immunocompetent patients. This has not been previously reported. should be considered in the differential diagnosis of epididymitis and epididymo-orchitis in both immunocompromised and immunocompetent patients.Healthcare providers should be aware of the increasing incidence of epididymitis and epididymo-orchitis caused by non-coliform bacteria in patients older than 35 years, especially in immunocompromised patients.

摘要

背景

附睾炎是成人阴囊疼痛的常见原因,在35岁以上患者中,大肠菌是最常见的分离出的病原体。

病例报告

一名51岁健康患者出现阴囊疼痛和肿胀,被发现患有附睾炎和睾丸炎以及菌血症,病原体为[未提及具体病菌名称],此前尚未有该病菌作为免疫功能正常患者附睾炎和菌血症病因的报道。

讨论

诊断性检查有助于确诊并检测出致病病原体。在所有疑似病例中,应进行尿液分析、尿培养以及尿液或尿道拭子的核酸扩增试验(NAATs)以检测[未提及具体病菌名称]。彩色多普勒超声检查在附睾炎中常显示附睾肿大增厚,附睾内多普勒波搏动增强。[未提及具体病菌名称]是多形性革兰氏阴性杆菌,通常寄生于人类呼吸道,并与多种临床病症相关。据报道,[未提及具体病菌名称]是青春期前男孩附睾炎的病因,少数病例与血培养阳性有关。在成人中,[未提及具体病菌名称]曾在附睾炎或附睾睾丸炎患者的尿液样本或尿道拭子中分离出。

结论

该病例突出了[未提及具体病菌名称]在免疫功能正常患者中导致附睾炎和菌血症的可能性。医疗保健人员在免疫功能正常和免疫功能低下患者附睾炎和附睾睾丸炎的鉴别诊断中应考虑到[未提及具体病菌名称]。

学习要点

[未提及具体病菌名称]可在免疫功能正常患者中导致附睾炎和菌血症。此前未有相关报道。在免疫功能低下和免疫功能正常患者附睾炎和附睾睾丸炎的鉴别诊断中应考虑到[未提及具体病菌名称]。医疗保健人员应意识到35岁以上患者,尤其是免疫功能低下患者中,非大肠菌引起的附睾炎和附睾睾丸炎发病率不断上升。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2060/10783462/c944cadf6dd0/4205_Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2060/10783462/c944cadf6dd0/4205_Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2060/10783462/c944cadf6dd0/4205_Fig1.jpg

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本文引用的文献

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Clinical significance and characterization of Haemophilus influenzae type b genogroup isolates from urine samples in an adult male population.成年男性人群尿液样本中 b 型流感嗜血杆菌基因组菌株的临床意义及特征分析
J Clin Microbiol. 2014 May;52(5):1745-8. doi: 10.1128/JCM.00506-14. Epub 2014 Mar 5.
2
Diagnosis and management of epididymitis.附睾炎的诊断与管理
Urol Clin North Am. 2008 Feb;35(1):101-8; vii. doi: 10.1016/j.ucl.2007.09.013.
3
Haemophilus influenzae epididymo-orchitis and bacteremia in a man infected with the human immunodeficiency virus.
一名感染人类免疫缺陷病毒的男性发生流感嗜血杆菌附睾炎-睾丸炎及菌血症。
Clin Infect Dis. 1994 Oct;19(4):768-9. doi: 10.1093/clinids/19.4.768.
4
Type B Hemophilus influenzae epididymo-orchitis in the prepubertal boy.青春期前男孩的B型流感嗜血杆菌附睾炎-睾丸炎
J Urol. 1986 Dec;136(6):1311-3. doi: 10.1016/s0022-5347(17)45326-2.