左心耳在全身内环境稳定、心律失常发生和其他方面的作用。
Role of the Left Atrial Appendage in Systemic Homeostasis, Arrhythmogenesis, and Beyond.
机构信息
The Kansas City heart rhythm institution and research foundation, HCA MIDWEST HEALTH, Second Floor, 5100 W 110th St, Overland Park, KS 66211, USA.
Division of Cardiology, Department of Internal Medicine, MSC10-5550, 1 University of New Mexico, Albuquerque, NM 87131, USA.
出版信息
Card Electrophysiol Clin. 2020 Mar;12(1):21-28. doi: 10.1016/j.ccep.2019.11.004.
The left atrial appendage (LAA) affects body homeostasis via atrial natriuretic peptide and the renin-angiotensin-aldosterone system and plays an important role in atrial compliance. Approximately 90% of clots in nonvalvular atrial fibrillation (AF) are formed in the LAA. AF is the most common sustained cardiac arrhythmia and is frequently associated with stroke. Because anticoagulation for stroke prophylaxis carries a higher bleeding risk, LAA closure via epicardial and endocardial approaches has gained popularity and is being increasingly pursued for arrhythmogenic, homeostatic, and stroke-reduction benefits. This review discusses the homeostatic role of the LAA and its involvement in arrhythmogenesis and thrombus formation.
左心耳（LAA）通过心房利钠肽和肾素-血管紧张素-醛固酮系统影响体内平衡，在心房顺应性中发挥重要作用。约 90%的非瓣膜性心房颤动（AF）中的血栓形成于 LAA。AF 是最常见的持续性心律失常，常与中风有关。由于抗凝预防中风的风险较高，通过心外膜和心内膜途径进行 LAA 闭合已变得流行，并越来越多地用于心律失常、体内平衡和减少中风的益处。本文综述了 LAA 的体内平衡作用及其在心律失常和血栓形成中的作用。
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