Garbin Livia Camargo, Olver Christine S
Department of Clinical Veterinary Sciences, School of Veterinary Medicine, Faculty of Medical Sciences, University of West Indies, St. Augustine, Trinidad and Tobago, West Indies.
Veterinary Diagnostic Laboratory, Clinical Pathology Section, Department of Microbiology, Immunology and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO.
J Equine Vet Sci. 2020 Mar;86:102820. doi: 10.1016/j.jevs.2019.102820. Epub 2019 Nov 16.
Autologous platelet-rich plasma (PRP) is a biological preparation made from the patient's own plasma that contains a platelet concentration above the whole blood baseline. Owing to the release of growth factors and other cytokines after degranulation, platelets have a central role in inflammation and in different stages of the healing process. For this reason, PRP-derived products have been used to enhance healing of musculoskeletal injuries and modulate progression of inflammatory processes, including osteoarthritis (OA). Osteoarthritis is one of the main causes of musculoskeletal disabilities in horses, and currently, there is no effective treatment for this disease. Treatments that focus on the modulation of inflammation and disease progression offer new hope for OA. Platelet-rich plasma provides a more practical and accessible option of therapy compared to other forms of biological treatment (i.e., stem cell therapies) and is believed to induce the production of functional matrix. However, several factors related to PRP production, including methods of preparation and application, and intraindividual variability, lead to an inconsistent product, precluding reliable conclusions about its efficacy for clinical use. The aim of this study was to review the benefits related to the clinical use of PRP in OA as well as factors that influence its use, the limitations of this treatment, and future directions of PRP research and therapy.
自体富血小板血浆（PRP）是一种由患者自身血浆制成的生物制剂，其血小板浓度高于全血基线水平。由于脱颗粒后生长因子和其他细胞因子的释放，血小板在炎症和愈合过程的不同阶段发挥着核心作用。因此，PRP衍生产品已被用于促进肌肉骨骼损伤的愈合，并调节包括骨关节炎（OA）在内的炎症过程的进展。骨关节炎是马匹肌肉骨骼残疾的主要原因之一，目前尚无针对该疾病的有效治疗方法。专注于调节炎症和疾病进展的治疗方法为OA带来了新的希望。与其他形式的生物治疗（即干细胞治疗）相比，富血小板血浆提供了一种更实用、更易获得的治疗选择，并且被认为能诱导功能性基质的产生。然而，与PRP制备相关的几个因素，包括制备和应用方法以及个体差异，导致产品不一致，从而无法就其临床疗效得出可靠结论。本研究的目的是综述PRP在OA临床应用中的益处、影响其使用的因素、该治疗方法的局限性以及PRP研究和治疗的未来方向。
