Institute of Orthopedics, Chinese PLA General Hospital, Beijing Key Lab of Regenerative Medicine in Orthopedics, Key Lab of Musculoskeletal Trauma & War Injuries, PLA, Beijing, P.R. China.
Graduate School of The North China University of Science and Technology, Hebei, P.R. China.
Tissue Eng Part B Rev. 2020 Dec;26(6):571-585. doi: 10.1089/ten.TEB.2019.0292. Epub 2020 Nov 3.
Platelet-rich plasma (PRP) is an autologous platelet concentrate prepared from the whole blood that is activated to release growth factors (GFs) and cytokines and has been shown to have the potential capacity to reduce inflammation and improve tissue anabolism for regeneration. The use of PRP provides a potential for repair due to its abundant GFs and cytokines, which are key in initiating and modulating regenerative microenvironments for soft and hard tissues. Among outpatients, orthopedic injuries are common and include bone defects, ligament injury, enthesopathy, musculoskeletal injury, peripheral nerve injury, chronic nonhealing wounds, articular cartilage lesions, and osteoarthritis, which are caused by trauma, sport-related or other types of trauma, or tumor resection. Surgical intervention is often required to treat these injuries. However, for numerous reasons regarding limited regeneration capacity and insufficient blood supply of the defect region, these treatments commonly result in unsatisfactory outcomes, and follow-up treatment is challenging. The aim of the present review is to explore future research in the field of PRP therapy in the treatment of diseases associated with orthopedic injuries. Impact statement In recent years, platelet-rich plasma (PRP) has become widely used in the treatment of diseases associated with orthopedic injuries, and the results of numerous studies are encouraging. Due to diseases associated with orthopedic injuries being common in clinics, as a conservative treatment, more and more doctors and patients are more likely to accept PRP. Importantly, PRP is a biological product of autologous blood that is obtained by a centrifugation procedure to enrich platelets from whole blood, resulting in few complications, such as negligible immunogenicity from an autologous source, and it is also simple to produce through an efficient and cost-effective method in a sterile environment. However, the applicability, advantages, and disadvantages of PRP therapy have not yet been fully elucidated. The aim of the present review is to explore future research in the field of PRP therapy in the treatment of diseases associated with orthopedic injuries, as well as to provide references for clinics.
富血小板血浆（PRP）是从全血中制备的自体血小板浓缩物，经过激活后释放生长因子（GFs）和细胞因子，具有减轻炎症和改善组织合成代谢以促进再生的潜力。PRP 的使用提供了修复的潜力，因为它富含 GFs 和细胞因子，这些因子在启动和调节软组织和硬组织的再生微环境中起着关键作用。在门诊患者中，骨科损伤很常见，包括骨缺损、韧带损伤、肌腱病、肌肉骨骼损伤、周围神经损伤、慢性不愈合伤口、关节软骨损伤和骨关节炎，这些损伤是由创伤、与运动相关或其他类型的创伤或肿瘤切除引起的。通常需要手术干预来治疗这些损伤。然而，由于缺陷区域的再生能力有限和血液供应不足等诸多原因，这些治疗方法通常导致结果不理想，后续治疗具有挑战性。本综述的目的是探讨 PRP 治疗在治疗与骨科损伤相关的疾病方面的未来研究。
近年来，富血小板血浆（PRP）在治疗与骨科损伤相关的疾病中得到了广泛应用，许多研究的结果令人鼓舞。由于与骨科损伤相关的疾病在临床上很常见，作为一种保守治疗方法，越来越多的医生和患者更愿意接受 PRP。重要的是，PRP 是一种自体血液的生物制品，通过离心程序从全血中富集血小板，从自体来源产生的免疫原性极小，并且可以在无菌环境中通过高效且具有成本效益的方法简单地生产。然而，PRP 治疗的适用性、优势和劣势尚未得到充分阐明。本综述的目的是探讨 PRP 治疗在治疗与骨科损伤相关的疾病方面的未来研究，为临床提供参考。
