Institute of Digestive Diseases, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China.
Department of Emergency, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
J Integr Med. 2020 May;18(3):196-202. doi: 10.1016/j.joim.2020.02.002. Epub 2020 Feb 7.
Hepatocellular carcinoma (HCC) is a prevalent and highly malignant cancer throughout the world. Effective treatment of this disease is impeded by the high rate of metastasis, recurrence, and chemoresistance. Recent studies have revealed the close relationship between the malignant phenotype of HCC and cancer stem cells (CSCs). Therefore, CSC-targeted therapy is considered a promising strategy to eradicate HCC. Traditional Chinese medicine (TCM) can be effective in preventing recurrence and metastasis of some advanced HCC. A growing amount of literature has discovered that extracts or compounds derived from TCM exert an anti-CSC effect. This review introduces some formulas and chemical compounds derived from TCMs that have been reported to inhibit CSCs of HCC; these TCM-related drugs may help to provide an alternative approach to help manage cancers, especially for HCC which has a great potential of metastasis, recurrence, and chemoresistance.
肝细胞癌（HCC）是一种在全球范围内普遍存在且高度恶性的癌症。由于转移、复发和化疗耐药率高，这种疾病的有效治疗受到阻碍。最近的研究揭示了 HCC 的恶性表型与癌症干细胞（CSC）之间的密切关系。因此，CSC 靶向治疗被认为是根除 HCC 的一种有前途的策略。中药（TCM）在预防某些晚期 HCC 的复发和转移方面可能有效。越来越多的文献发现，源自中药的提取物或化合物具有抗 CSC 的作用。本综述介绍了一些已报道的抑制 HCC CSCs 的 TCM 方剂和化学化合物；这些与中药相关的药物可能有助于提供一种替代方法来帮助治疗癌症，特别是对于具有高转移、复发和化疗耐药性的 HCC 来说。
