Department of Psychiatry, Taoyuan Psychiatric Centre, Ministry of Health and Welfare, Taoyuan City, Taiwan; Department of Public Health and Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan; Research Center of Big Data and Meta-analysis, Wan Fang Hospital, Taipei Medical University, Taiwan.
Research Center of Big Data and Meta-analysis, Wan Fang Hospital, Taipei Medical University, Taiwan; Department of Dermatology, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan; Department of Dermatology, School of Medicine and College of Medicine, Taipei Medical University, Taipei, Taiwan.
Neurosci Biobehav Rev. 2020 May;112:336-344. doi: 10.1016/j.neubiorev.2020.02.007. Epub 2020 Feb 14.
This research is aimed to systematically review heart rate variability (HRV) findings of functional somatic syndromes (FSSs) and somatic symptom disorders (SSDs), and to compare the HRV values between FSSs/SSDs patients and healthy individuals. We included clinical studies assessing HRV (including baseline HRV and HRV reactivity) in FSSs/SSDs and healthy participants. We searched PubMed, Embase, PsycINFO, MEDLINE, and Web of Science databases from the earliest available date to June 2019. Eighty-five studies comprising 3242 FSSs/SSDs patients and 2321 controls were included in the main meta-analysis; the baseline HRV value was significantly lower compared to healthy individuals (Hedges'g, -0.43; 95 % CI, -0.54 to -0.30; p < .001), with the largest effect size in fibromyalgia patients. A significant lower HRV was also found for total variability (Hedges'g, -0.56; 95 % CI, -0.77 to -0.36) and specific parasympathetic indices (Hedges'g, -0.41, 95 % CI; -0.54 to -0.30). HRV reactivity was significantly lower in FSSs/SSDs patients (Hedges'g, -0.42; 95 % CI, -0.64 to -0.20). Our results support the notion that FSSs/SSDs patients have significantly lower HRV than healthy individuals.
本研究旨在系统回顾功能性躯体综合征（FSS）和躯体症状障碍（SSD）的心率变异性（HRV）研究结果，并比较 FSS/SSD 患者与健康个体的 HRV 值。我们纳入了评估 FSS/SSD 患者和健康参与者 HRV（包括基线 HRV 和 HRV 反应性）的临床研究。我们检索了 PubMed、Embase、PsycINFO、MEDLINE 和 Web of Science 数据库，检索时间截至 2019 年 6 月。主要荟萃分析纳入了 85 项研究，共包括 3242 例 FSS/SSD 患者和 2321 例对照者；与健康个体相比，FSS/SSD 患者的基线 HRV 值显著降低（Hedges'g，-0.43；95%CI，-0.54 至-0.30；p<.001），其中纤维肌痛患者的效应量最大。还发现总变异性（Hedges'g，-0.56；95%CI，-0.77 至-0.36）和特定的副交感神经指数（Hedges'g，-0.41，95%CI；-0.54 至-0.30）也显著降低。FSS/SSD 患者的 HRV 反应性也显著降低（Hedges'g，-0.42；95%CI，-0.64 至-0.20）。我们的研究结果支持这样一种观点，即 FSS/SSD 患者的 HRV 明显低于健康个体。
