Bruti Gianluca, Foggetti Paola
Eurekacademy, Center for International Studies of Cognitive Neurosciences and Integrated Medicine, Antonio Bertoloni 26/C, 00197 Rome, Italy.
Biomedicines. 2024 Aug 2;12(8):1744. doi: 10.3390/biomedicines12081744.
Although the pathophysiology of fibromyalgia syndrome has been better understood in recent decades, a unified model of its pathogenesis and an effective therapeutic approach are still far from being realized. The main aim of this article will be to delve into the fundamental mechanisms of the pathophysiology of fibromyalgia conceptualized as stress intolerance syndrome. Using the biopsychosocial model of chronic pain syndromes, we will describe the potential role of the attachment system, C-tactile fibers, and oxytocinergic system dysfunction in the pathophysiology of fibromyalgia syndrome and other central sensitivity syndromes. At the end of the article, the therapeutic implications of this new global and translational pathophysiological model will be briefly discussed.
尽管近几十年来纤维肌痛综合征的病理生理学已得到更好的理解，但其发病机制的统一模型和有效的治疗方法仍远未实现。本文的主要目的将是深入探讨被概念化为应激不耐受综合征的纤维肌痛病理生理学的基本机制。使用慢性疼痛综合征的生物心理社会模型，我们将描述依恋系统、C触觉纤维和催产素能系统功能障碍在纤维肌痛综合征和其他中枢敏化综合征病理生理学中的潜在作用。在文章结尾，将简要讨论这种新的全球和转化病理生理模型的治疗意义。
