Gracheva Nadezda, Carzaniga Tommaso Stefano, Schibli Roger, Braccini Saverio, van der Meulen Nicholas P
Center for Radiopharmaceutical Sciences ETH-PSI-USZ, Paul Scherrer Institute, Villigen-PSI, Switzerland.
Albert Einstein Center for Fundamental Physics (AEC), Laboratory for High Energy Physics (LHEP), University of Bern, Bern, Switzerland.
Appl Radiat Isot. 2020 May;159:109079. doi: 10.1016/j.apradiso.2020.109079. Epub 2020 Feb 12.
Er, a pure Auger-electron emitter, could be an attractive candidate for targeted radionuclide therapy. Auger electrons possess short penetration paths with high linear energy transfer. In this study, experimental cross-sections of the Ho(p, n)Er nuclear reaction were measured and targets irradiated with protons using Injector II cyclotron at Paul Scherrer Institute (Switzerland) and the 18 MeV medical cyclotron laboratory at the University Hospital in Bern. A purification method was developed in order to obtain Er suitable for in vivo applications.
铒是一种纯俄歇电子发射体，可能是靶向放射性核素治疗的一个有吸引力的候选者。俄歇电子具有短穿透路径和高传能线密度。在本研究中，测量了钬（p，n）铒核反应的实验截面，并使用瑞士保罗·谢尔研究所的注入器II回旋加速器和伯尔尼大学医院的18 MeV医用回旋加速器实验室用质子辐照靶材。开发了一种纯化方法以获得适用于体内应用的铒。
