Noll B, Göke B, Printz H, Gerberding J, Keim V, Arnold R
Zentrum Innere Medizin der Philipps Universität Marburg.
Z Gastroenterol. 1988 Jun;26(6):331-6.
Thyroxine modulates the ontogenic changes of animal tissues. In this study, the effects of experimental hyperthyroidism on the adult rat pancreas, small intestine, and serum gastrin were evaluated. Hyperthyroidism was induced by oral feeding of thyroxine (T4) in increasing dosages (150-450 micrograms/kg body weight; 3 weeks) and controlled by measurements of the circulating hormones. The increase of thyroid hormones in blood (T4 ng/dl: thyroxine-treated rats 10.8 vs. controls 3.3; p less than 0.01; given are means) was accompanied by hypergastrinemia (IR-gastrin pg/ml: T4-treated rats 169 vs. controls 25; p less than 0.05). The T4-treated animals consumed more food but lost about 20 g of their initial body weight. Pancreatic wet weight (g: T4-treatment 1.72 vs. controls 1.42; p less than 0.05), DNA (micrograms/g body weight: T4-treatment 2.42 vs. controls 1.5; p less than 0.05), and protein (micrograms/g body weight: T4-treatment 131.7 vs. controls 63.5; p less than 0.05) were increased, whereas no pronounced influence on pancreatic amylase, trypsin, and chymotrypsin was found. The gut wet weight after thyroxine administration (18.1 g vs. 15.4 g of controls; p less than 0.05) was elevated, but length, DNA, protein, and brush border enzyme activities remained unaltered. Our data demonstrate in adult rats a small but significant trophic response of pancreas and gut to repeated oral thyroxine administration.
甲状腺素调节动物组织的个体发育变化。在本研究中，评估了实验性甲状腺功能亢进对成年大鼠胰腺、小肠和血清胃泌素的影响。通过口服递增剂量的甲状腺素（T4）（150 - 450微克/千克体重；3周）诱导甲状腺功能亢进，并通过测量循环激素进行控制。血液中甲状腺激素的增加（T4纳克/分升：甲状腺素处理的大鼠为10.8，对照组为3.3；p < 0.01；给出的是平均值）伴随着高胃泌素血症（免疫反应性胃泌素皮克/毫升：T4处理的大鼠为169，对照组为25；p < 0.05）。T4处理的动物食量增加，但初始体重减轻了约20克。胰腺湿重（克：T4处理组为1.72，对照组为1.42；p < 0.05）、DNA（微克/克体重：T4处理组为2.42，对照组为1.5；p < 0.05）和蛋白质（微克/克体重：T4处理组为131.7，对照组为63.5；p < 0.05）增加，而对胰腺淀粉酶、胰蛋白酶和糜蛋白酶未发现明显影响。给予甲状腺素后肠道湿重升高（18.1克对对照组的15.4克；p < 0.05），但长度、DNA、蛋白质和刷状缘酶活性保持不变。我们的数据表明，成年大鼠胰腺和肠道对重复口服甲状腺素给药有轻微但显著的营养反应。
