Department of Food and Human Health Sciences, Graduate School of Human Life Science, Osaka City University, Osaka, Japan.
J Med Food. 2020 May;23(5):465-475. doi: 10.1089/jmf.2019.4490. Epub 2020 Feb 18.
1'-Acetoxychavicol acetate (ACA) is found in the rhizomes or seeds of and , which are used as traditional spices in cooking and traditional medicines in Southeast Asia. ACA possesses numerous medicinal properties. Those include anticancer, antiobesity, antiallergy, antimicrobial, antidiabetic, gastroprotective, and anti-inflammatory activities. ACA is also observed to exhibit antidementia activity. Recent studies have demonstrated that combining ACA with other substances results in synergistic anticancer effects. The structural factors that regulate the activity of ACA include (1) the acetyl group at position 1', (2) the acetyl group at position 4, and (3) the unsaturated double bond between positions 2' and 3'. ACA induces the activation of AMP-activated protein kinase (AMPK), which regulates the signal transduction pathways, and has an important role in the prevention of diseases, including cancer, obesity, hyperlipidemia, diabetes, and neurodegenerative disorders. Such findings suggest that AMPK has a central role in different pharmacological functions of ACA, and ACA is useful for the prevention of life-threatening diseases. However, more studies should be performed to evaluate the clinical effects of ACA and to better understand its potential.
1'-乙酰氧基胡椒酚乙酸酯（ACA）存在于 和 的根茎或种子中，在东南亚被用作烹饪中的传统香料和传统药物。ACA 具有许多药用特性。这些特性包括抗癌、抗肥胖、抗过敏、抗菌、抗糖尿病、胃保护和抗炎活性。ACA 还被观察到具有抗痴呆活性。最近的研究表明，将 ACA 与其他物质结合使用会产生协同的抗癌作用。调节 ACA 活性的结构因素包括 (1) 1'位的乙酰基，(2) 4 位的乙酰基，和 (3) 2'位和 3'位之间的不饱和双键。ACA 诱导 AMP 激活蛋白激酶 (AMPK) 的激活，AMPK 调节信号转导途径，在预防癌症、肥胖、高血脂、糖尿病和神经退行性疾病等疾病方面发挥着重要作用。这些发现表明，AMPK 在 ACA 的不同药理作用中起着核心作用，ACA 可用于预防危及生命的疾病。然而，还需要进行更多的研究来评估 ACA 的临床效果，并更好地了解其潜力。
