Department of Neonatology, Harran University School of Medicine, Sanliurfa, Turkey.
Am J Perinatol. 2021 Aug;38(10):1062-1069. doi: 10.1055/s-0040-1701610. Epub 2020 Feb 18.
The aim of this study is to assess the effects of administering 20 mg/kg loading dose of caffeine citrate intravenously on splanchnic oxygenation in preterm infants.
The infants with a gestational age (GA) of <34 weeks who were administered with a 20 mg/kg intravenous loading dose of caffeine citrate within 48 hours after birth were investigated prospectively. Regional splanchnic oxygen saturation (rsSO) and splanchnic fractional tissue oxygen extraction rate (sFTOE) were measured using near-infrared spectroscopy before caffeine infusion, immediately after caffeine infusion and 1, 2, 3, 4, and 6 hours (h) after dose completion; postdose values were compared with predose values.
A total of 41 infants with a mean GA of 29.2 ± 1.6 weeks and birth weight of 1,315 ± 257 g as well as postnatal age of 32.2 ± 10.8 hours were included in the study. rsSO significantly reduced from 63.1 to 57.5% immediately after caffeine infusion, 55.1% after 1 hour, and 55.2% after 2 hours with partial recovery at 3-hour postdose. sFTOE increased correspondingly.
Caffeine reduces splanchnic oxygenation and increases splanchnic oxygen extraction for at least 2 hours with partial recovery to predose levels at 3-hour postdose.
本研究旨在评估静脉注射 20mg/kg 枸橼酸咖啡因负荷剂量对早产儿内脏氧合的影响。
前瞻性研究了出生后 48 小时内接受 20mg/kg 静脉注射咖啡因枸橼酸盐负荷剂量的胎龄（GA）<34 周的婴儿。使用近红外光谱仪在咖啡因输注前、输注后即刻以及剂量完成后 1、2、3、4 和 6 小时（h）测量局部内脏氧饱和度（rsSO）和内脏组织氧摄取分数（sFTOE）；与预剂量值相比，比较了后剂量值。
共有 41 名婴儿纳入研究，平均 GA 为 29.2±1.6 周，出生体重为 1315±257g，出生后年龄为 32.2±10.8h。rsSO 立即从咖啡因输注后的 63.1%降至 57.5%，1 小时后降至 55.1%，2 小时后降至 55.2%，3 小时后部分恢复至预剂量水平。sFTOE 相应增加。
咖啡因至少在 2 小时内降低内脏氧合，并增加内脏氧摄取，在 3 小时后部分恢复到预剂量水平。
