Vasil'eva G I, Doroshenko E P, Kiseleva A K
Zh Mikrobiol Epidemiol Immunobiol. 1988 Sep(9):63-6.
The multiplication of Y. pestis vaccinal strain inside peritoneal macrophages of guinea pigs and white mice in vitro leads to an essential increase in its latent virulence. This effect is most pronounced when guinea pig macrophages are used. Changes in the latent virulence of Y. pestis vaccinal strains, occurring in the process of their passage inside macrophages in vitro, correlate with those observed in vivo, i.e. in animal experiments.
鼠疫耶尔森氏菌疫苗株在豚鼠和小白鼠腹膜巨噬细胞内的体外增殖会导致其潜在毒力显著增加。使用豚鼠巨噬细胞时这种效应最为明显。鼠疫耶尔森氏菌疫苗株在体外巨噬细胞内传代过程中发生的潜在毒力变化与在体内（即动物实验中）观察到的变化相关。
