Prud'Homme M J
I.N.R.A., Physiologie de la Reproduction, Nouzilly, France.
Acta Physiol Hung. 1988;71(4):485-9.
The electromyographic activity (EMG) of the uterus was recorded in vivo in 8 unanaesthetized ewes from the 140th day of gestation up to parturition. The effects on uterine activity of treatments with an alpha 1-receptor blocker (prazosin) and an alpha 2-receptor blocker (yohimbine) were studied. During the last days of gestation, EMG activity consisted of periodic active phases (1-2/h). During the last 16-17 hours, uterine activity increased sharply; this period was referred to a labour. Intravenous perfusion of prazosin (0.03 mg/kg/mn over 1 h) or intravenous injections (1 mg/kg) did not modify uterine activity either before or during labour. Intravenous perfusion of yohimbine (0.03 mg/kg/mn during 1h) inhibited uterine activity before and during labour. In all cases, lambing occurred between the 142nd and 145th day of gestation, which corresponds to the normal lambing period. These results suggest that, in the ewe, uterine alpha 2-receptors are important for normal uterine activity at the end of gestation and in. parturition.
在8只未麻醉的母羊体内，从妊娠第140天直至分娩，记录子宫的肌电图活动（EMG）。研究了α1受体阻滞剂（哌唑嗪）和α2受体阻滞剂（育亨宾）对子宫活动的影响。在妊娠最后几天，肌电图活动由周期性的活跃期组成（每小时1 - 2次）。在最后16 - 17小时内，子宫活动急剧增加；这一时期被称为分娩期。静脉输注哌唑嗪（1小时内0.03毫克/千克/分钟）或静脉注射（1毫克/千克）在分娩前或分娩期间均未改变子宫活动。静脉输注育亨宾（1小时内0.03毫克/千克/分钟）在分娩前和分娩期间均抑制子宫活动。在所有情况下，产羔发生在妊娠第142天至145天之间，这与正常产羔期相符。这些结果表明，在母羊中，子宫α2受体对妊娠末期和分娩时的正常子宫活动很重要。
