CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, Liaoning, 116023, People's Republic of China.
CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, Liaoning, 116023, People's Republic of China; University of Chinese Academy of Sciences, Beijing, 100049, People's Republic of China.
Talanta. 2020 May 1;211:120712. doi: 10.1016/j.talanta.2020.120712. Epub 2020 Jan 3.
Online measuring end-tidal propofol concentration during balanced anesthesia is important for anesthetists to learn the patient's anesthesia depth as exhaled propofol concentration is well related to blood propofol concentration. In previous work, exhaled propofol was detected using acetone assisted negative photoionization ion mobility spectrometer, however, the existence of high concentration sevoflurane interfered the response of propofol. In this work, an anisole assisted photoionization ion mobility spectrometer operated in positive mode was developed to sensitively and selectively measure the end-tidal propofol by eliminating the interferences of exhaled humidity and sevoflurane during balanced anesthesia. Anisole molecular ion is stable enough not to go under proton transfer reaction with water presents in the exhaled breath. Hence, the exhaled humidity related peaks were eliminated and only one propofol product ion peak (K = 1.50 cm V s) was observed. The relative standard deviation (RSD) ranging from 0.64%-0.91% showed good repeatability and the quantitative range was 0.2-40 ppbv with a response time of 4 s. Finally, the performance of the proposed method was demonstrated by monitoring end-tidal propofol of balanced anesthetized patients during gastric cancer surgery.
在平衡麻醉期间在线测量呼气末异丙酚浓度对于麻醉师了解患者的麻醉深度非常重要，因为呼出的异丙酚浓度与血液中的异丙酚浓度密切相关。在以前的工作中，使用丙酮辅助的负光电离离子淌度谱仪检测呼出的异丙酚，然而，高浓度七氟醚的存在会干扰异丙酚的响应。在这项工作中，开发了一种茴香醚辅助的正光电离离子淌度谱仪，用于在平衡麻醉期间通过消除呼出湿度和七氟醚的干扰来灵敏且选择性地测量呼气末异丙酚。茴香醚分子离子足够稳定，不会与呼出空气中存在的水发生质子转移反应。因此，消除了与呼出湿度相关的峰，仅观察到一个异丙酚产物离子峰（K=1.50cmVs）。相对标准偏差（RSD）在 0.64%-0.91%之间，显示出良好的重复性，定量范围为 0.2-40ppbv，响应时间为 4s。最后，通过监测胃癌手术期间平衡麻醉患者的呼气末异丙酚来验证所提出方法的性能。
