Prognostic value of FDG PET/CT volumetric parameters in the survival prediction of patients with pancreatic cancer.

PURPOSE

To investigate the value of FDG PET/CT volumetric parameters in the prediction of overall survival (OS) in patients with pancreatic cancer and also, assess their independence relative to well-established clinico-pathological variables.

METHODS

We conducted a retrospective analysis of patients with a confirmed diagnosis of pancreatic cancer who underwent FDG PET/CT. The tumour maximum standardised uptake value (SUV) in addition to SUV, metabolic tumour volume (MTV) and total lesion glycolysis (TLG) were calculated. The prognostic value of FDG PET/CT and clinico-pathological parameters for OS were assessed using univariate and multivariable analyses.

RESULTS

A sum of 89 patients were analysed in this study. Median survival for patients categorised as having high TLG (≥55) and low TLG (<55) was 18 vs 5 months (p < 0.001). Similarly, the respective high vs low SUV, MTV and SUVmax were 18 vs 6 months (p = 0.001), 16 vs 6 months (p = 0.002) and 18 vs 6 months (p = 0.001). Univariate analysis showed SUV SUV MTV, TLG, tumour size, tumour differentiation and presence of distant metastasis as prognostic factors for OS. On multivariable analysis, TLG (HR 2.0, 95% CI 1.26-3.18, p = 0.004) and the presence of distant metastasis (HR 3.37, 95% CI 1.97-5.77, p < 0.001) emerged as independent prognostic factors. Subgroup analysis identified TLG as the only significant PET metric after adjusting for the presence of distant metastasis.

CONCLUSIONS

FDG PET/CT is a useful tool in the preoperative evaluation of patients with pancreatic cancer. Tumour TLG offer an independent prognostic value in both potentially operable and metastatic disease settings.