平均动脉压与 2 型糖尿病风险的关联：中国农村队列研究。
Association between mean arterial pressure and risk of type 2 diabetes mellitus: The Rural Chinese Cohort Study.
机构信息
Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, People's Republic of China.
Department of Preventive Medicine, Shenzhen University Health Science Center, Shenzhen, Guangdong, People's Republic of China.
出版信息
Prim Care Diabetes. 2020 Oct;14(5):448-454. doi: 10.1016/j.pcd.2020.01.007. Epub 2020 Feb 15.
AIMS
Limited evidence is available on the association of mean arterial pressure and risk of type 2 diabetes mellitus (T2DM) among Chinese people. We aimed to investigate the association between MAP and risk of T2DM in rural Chinese adults.
METHODS
We performed a cohort study of 12,284 eligible participants (4668 men and 7616 women) without T2DM at baseline. Cox proportional-hazards models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for the association of MAP with risk of T2DM. Restricted cubic spline models were used to evaluate the dose-response association between MAP and risk of T2DM.
RESULTS
During a median of 6.01 years follow-up (73,403.52 person-years), T2DM developed in 847 participants (318 men and 529 women). In the multivariable-adjusted models, risk of T2DM was significantly higher for women with the third (90-100mmHg) and fourth MAP categories (≥100mmHg) than the first category (<80mmHg) after adjusting for confounders (HR=1.74 [95% CI 1.14-2.68] and 1.84 [1.20-2.83]). Restricted cubic spline analysis revealed increased risk of T2DM with increasing MAP for women.
CONCLUSION
High MAP was related to high incident T2DM among women in China.
目的
关于平均动脉压（MAP）与中国人群 2 型糖尿病（T2DM）风险之间的关联，现有证据有限。本研究旨在调查中国农村成年人中 MAP 与 T2DM 风险之间的关系。
方法
我们对 12284 名基线时无 T2DM 的合格参与者（男性 4668 名，女性 7616 名）进行了队列研究。采用 Cox 比例风险模型估计 MAP 与 T2DM 风险之间的关联的风险比（HR）和 95%置信区间（CI）。采用限制性立方样条模型评估 MAP 与 T2DM 风险之间的剂量-反应关系。
结果
在中位 6.01 年的随访期间（73403.52 人年），847 名参与者（男性 318 名，女性 529 名）发生了 T2DM。在多变量调整模型中，与第一类别（<80mmHg）相比，女性中 MAP 处于第三（90-100mmHg）和第四类别（≥100mmHg）的 T2DM 风险明显更高（调整混杂因素后 HR=1.74[95%CI 1.14-2.68]和 1.84[1.20-2.83]）。限制性立方样条分析显示，随着 MAP 的增加，女性 T2DM 的风险也随之增加。
结论
在中国女性中，高 MAP 与较高的 T2DM 发生率相关。
Zotero 插件