Centre for Forensic Science, University of Technology Sydney, Sydney, NSW 2007, Australia.
Centre for Forensic Science, University of Technology Sydney, Sydney, NSW 2007, Australia.
Forensic Sci Int. 2020 Apr;309:110176. doi: 10.1016/j.forsciint.2020.110176. Epub 2020 Jan 30.
This work examines organic impurity profiles of 3,4-methylenedioxymethamphetamine (MDMA) that has been synthesised from the "pre-precursors" catechol (1,2-dihydroxybenzene) and eugenol, via a safrole intermediate. MDMA was synthesised from the catechol- and eugenol-derived safrole intermediate via two routes, which resulted in the synthesis of MDMA from catechol via two routes (Route 1A and 1B) and from eugenol via two routes (Route 2A and 2B). Twelve organic impurities were identified in MDMA synthesised via Routes 1A and 1B, and eleven organic impurities were identified in MDMA synthesised via Routes 2A and 2B. Route specific organic impurities were identified in MDMA that indicated the "pre-precursors" catechol and eugenol were used in the respective synthetic routes. Route specific organic impurities were also identified in MDMA that indicated the route used to synthesise safrole from the "pre-precursor" and the route used to synthesise MDMA from safrole. Thus, the use of the "pre-precursors" catechol and eugenol and the synthetic route utilised could be ascertained by the organic impurity profiling of MDMA under the conditions used here.
这项工作研究了 3,4-亚甲二氧基甲基苯丙胺（MDMA）的有机杂质谱，该物质是由“前体”儿茶酚（1,2-二羟基苯）和丁香酚通过苯丙烯中间体合成的。MDMA 是由儿茶酚和丁香酚衍生的苯丙烯中间体通过两条途径合成的，这导致 MDMA 可以通过两条途径从儿茶酚合成（途径 1A 和 1B），也可以从丁香酚合成（途径 2A 和 2B）。在通过途径 1A 和 1B 合成的 MDMA 中鉴定出了 12 种有机杂质，在通过途径 2A 和 2B 合成的 MDMA 中鉴定出了 11 种有机杂质。在 MDMA 中鉴定出了特定于途径的有机杂质，这表明“前体”儿茶酚和丁香酚被用于各自的合成途径。在 MDMA 中还鉴定出了特定于途径的有机杂质，这表明了从“前体”合成苯丙烯的途径以及从苯丙烯合成 MDMA 的途径。因此，在本研究中使用的条件下，可以通过 MDMA 的有机杂质分析来确定儿茶酚和丁香酚的“前体”的使用情况和合成途径。
