营养感应信号对成年雌性生殖干细胞的调控。
Regulation of adult female germline stem cells by nutrient-responsive signaling.
机构信息
Molecular and Biological Agricultural Sciences Program, Taiwan International Graduate Program, National Chung Hsing University and Academia Sinica, Taipei 11529, Taiwan; Graduate Institute of Biotechnology, National Chung Hsing University, Taichung 40227, Taiwan; Institute of Cellular and Organismic Biology, Academia Sinica, Taipei 11529, Taiwan.
Molecular and Biological Agricultural Sciences Program, Taiwan International Graduate Program, National Chung Hsing University and Academia Sinica, Taipei 11529, Taiwan; Biotechnology Center, National Chung Hsing University, Taichung 40227, Taiwan; Institute of Cellular and Organismic Biology, Academia Sinica, Taipei 11529, Taiwan.
出版信息
Curr Opin Insect Sci. 2020 Feb;37:16-22. doi: 10.1016/j.cois.2019.10.005. Epub 2020 Jan 30.
Insect oogenesis is greatly affected by nutrient availability. When nutrients are abundant, oocytes are rapidly generated, but the process is slowed to conserve energy under nutrient-deficient conditions. To properly allocate limited resources toward oogenesis, systemic factors coordinate the behavioral response of ovarian germline stem cells (GSCs) to nutritional inputs by acting on the GSC itself, GSC supporting cells (the niche), or the adipose tissue surrounding the ovary. In this review, we describe current knowledge of the Drosophila ovarian GSC-niche-adipocyte system and major nutrient sensing pathways (insulin/IGF signaling, TOR signaling, and GCN2-dependent amino acid sensing) that intrinsically or extrinsically regulate GSC responses to nutrient signals.
昆虫的卵子发生受营养物质可用性的影响很大。当营养物质丰富时，卵母细胞会迅速生成，但在营养缺乏的情况下，卵子发生的过程会减缓以节省能量。为了将有限的资源正确分配到卵子发生中，全身性因素通过作用于卵原干细胞（GSCs）本身、GSC 支持细胞（生态位）或卵巢周围的脂肪组织，来协调卵巢生殖细胞干细胞（GSCs）对营养输入的行为反应。在这篇综述中，我们描述了果蝇卵巢 GSC-生态位-脂肪细胞系统以及主要的营养感应途径（胰岛素/IGF 信号、TOR 信号和 GCN2 依赖性氨基酸感应）的现有知识，这些途径内在或外在地调节 GSC 对营养信号的反应。
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