评估剂量分割多黏菌素 B 在急性肾损伤中的应用：一种转化性大鼠模型。
Evaluation of Dose-Fractionated Polymyxin B on Acute Kidney Injury Using a Translational Rat Model.
机构信息
Midwestern University, Downers Grove, Illinois, USA.
Midwestern University, Chicago College of Pharmacy Pharmacometrics Center of Excellence, Downers Grove, Illinois, USA.
出版信息
Antimicrob Agents Chemother. 2020 Apr 21;64(5). doi: 10.1128/AAC.02300-19.
Abstract
We investigated dose-fractionated polymyxin B (PB) on acute kidney injury (AKI). PB at 12 mg of drug/kg of body weight per day (once, twice, and thrice daily) was administered in rats over 72 h. The thrice-daily group demonstrated the highest KIM-1 increase ( = 0.018) versus that of the controls ( = 0.99) and histopathological damage ( = 0.013). A three-compartment model best described the data (bias, 0.129 mg/liter; imprecision, 0.729 mg/liter; , 0.652,). Area under the concentration-time curve at 24 h (AUC) values were similar ( = 0.87). The thrice-daily dosing scheme resulted in the most PB-associated AKI in a rat model.
摘要
我们研究了分剂量多黏菌素 B（PB）对急性肾损伤（AKI）的影响。在 72 小时内，将每天 12 毫克/公斤体重的 PB 分剂量（每日一次、两次和三次）给予大鼠。与对照组（=0.99）和组织病理学损伤（=0.013）相比，每日三次组的 KIM-1 增加最高（=0.018）。三室模型最能描述数据（偏差，0.129mg/l；不精密度，0.729mg/l；，0.652，）。24 小时浓度-时间曲线下面积（AUC）值相似（=0.87）。在大鼠模型中，每日三次给药方案导致与 PB 相关的 AKI 最多。
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