2016 年美国哨点监测中显示对阿奇霉素耐药性降低的淋病奈瑟菌菌株的基因组特征
Genomic Characterization of Neisseria gonorrhoeae Strains from 2016 U.S. Sentinel Surveillance Displaying Reduced Susceptibility to Azithromycin.
机构信息
Division of STD Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
Division of STD Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
出版信息
Antimicrob Agents Chemother. 2020 Apr 21;64(5). doi: 10.1128/AAC.02420-19.
Abstract
In 2016, the proportion of isolates with reduced susceptibility to azithromycin rose to 3.6%. A phylogenetic analysis of 334 isolates collected in 2016 revealed a single, geographically diverse lineage of isolates with MICs of 2 to 16 μg/ml that carried a mosaic-like locus, whereas the majority of isolates with MICs of ≥16 μg/ml appeared sporadically and carried 23S rRNA mutations. Continued molecular surveillance of isolates will identify new resistance mechanisms.
摘要
2016 年，对阿奇霉素敏感性降低的 分离株的比例上升至 3.6%。对 2016 年采集的 334 株 分离株进行的系统发育分析显示，存在单一的、地理上多样化的分离株谱系，这些分离株的 MIC 值为 2 至 16μg/ml，携带镶嵌样 基因座，而 MIC 值≥16μg/ml 的大多数分离株则呈散在分布，并携带 23S rRNA 突变。对 分离株的持续分子监测将确定新的耐药机制。
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