美国对阿奇霉素耐药的淋病奈瑟菌临床分离株在所有 23S rRNA 等位基因和 mtrR 编码区均存在突变。
Clinical Neisseria gonorrhoeae isolates in the United States with resistance to azithromycin possess mutations in all 23S rRNA alleles and the mtrR coding region.
机构信息
San Francisco Department of Public Health Laboratory, San Francisco, California 94102, USA.
出版信息
Microb Drug Resist. 2011 Sep;17(3):425-7. doi: 10.1089/mdr.2010.0199. Epub 2011 Apr 14.
PMID:21492017
Abstract
We identified strains of Neisseria gonorrhoeae in San Diego County, California, that possess high levels of resistance to azithromycin (8.0-16.0 μg/ml MIC). These isolates contain a combination of mutations in both the 23S rRNA loci and mtrR genes. This is the first description of such isolates in the United States.
摘要
我们在加利福尼亚州圣地亚哥县鉴定出了对阿奇霉素（8.0-16.0μg/ml MIC）具有高水平耐药性的淋病奈瑟菌菌株。这些分离株同时在 23S rRNA 基因座和 mtrR 基因中存在突变。这是在美国首次对这类分离株的描述。
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