重排 AAA+ 结构以容纳折叠的底物。
Rearranging AAA+ architecture to accommodate folded substrates.
机构信息
Department of Biochemistry, School of Medicine, University of Utah, Salt Lake City, UT, USA.
出版信息
Nat Struct Mol Biol. 2020 Mar;27(3):225-226. doi: 10.1038/s41594-020-0389-5.
Abstract
Many AAA+ ATPases assemble as hexamers to unfold protein substrates using a hand-over-hand, threading mechanism, but the Bcs1 AAA+ ATPase facilitates mitochondrial membrane translocation of the folded, iron-sulfur Rieske protein. Two reports now reveal that Bcs1 adopts an unusual heptameric configuration and provide insights into a non-canonical translocation mechanism.
摘要
许多 AAA+ ATP 酶组装成六聚体，使用手对手、穿线机制展开蛋白质底物，但 Bcs1 AAA+ ATP 酶促进折叠的、含铁硫 Rieske 蛋白的线粒体膜易位。现在有两份报告揭示了 Bcs1 采用了一种不寻常的七聚体构象，并提供了对非典型易位机制的深入了解。
相似文献
1
Rearranging AAA+ architecture to accommodate folded substrates.重排 AAA+ 结构以容纳折叠的底物。
Nat Struct Mol Biol. 2020 Mar;27(3):225-226. doi: 10.1038/s41594-020-0389-5.
2
Polypeptide translocation by the AAA+ ClpXP protease machine.由AAA+ ClpXP蛋白酶机器进行的多肽转运
Chem Biol. 2009 Jun 26;16(6):605-12. doi: 10.1016/j.chembiol.2009.05.007.
3
Electron cryomicroscopy structure of a membrane-anchored mitochondrial AAA protease.电子冷冻显微镜下观察到的膜锚定的线粒体 AAA 蛋白酶结构。
J Biol Chem. 2011 Feb 11;286(6):4404-11. doi: 10.1074/jbc.M110.158741. Epub 2010 Dec 8.
4
Structural snapshots of the cellular folded protein translocation machinery Bcs1.Bcs1 细胞折叠蛋白易位机械的结构快照。
FEBS J. 2021 May;288(9):2870-2883. doi: 10.1111/febs.15576. Epub 2020 Oct 9.
5
Bacterial sec-translocase unfolds and translocates a class of folded protein domains.细菌Sec转位酶可使一类折叠的蛋白质结构域解折叠并进行转位。
J Mol Biol. 2007 Sep 14;372(2):422-33. doi: 10.1016/j.jmb.2007.07.003. Epub 2007 Jul 12.
6
Membrane protein degradation by AAA proteases in mitochondria: extraction of substrates from either membrane surface.线粒体中AAA蛋白酶介导的膜蛋白降解：从任一膜表面提取底物
Mol Cell. 2000 Apr;5(4):629-38. doi: 10.1016/s1097-2765(00)80242-7.
7
AAA proteins: in search of a common molecular basis. International Meeting on Cellular Functions of AAA Proteins.AAA蛋白：探寻共同的分子基础。AAA蛋白细胞功能国际会议。
EMBO Rep. 2001 Nov;2(11):980-5. doi: 10.1093/embo-reports/kve229.
8
Vps4 disassembles an ESCRT-III filament by global unfolding and processive translocation.Vps4通过全局展开和持续性易位来拆解ESCRT-III细丝。
Nat Struct Mol Biol. 2015 Jun;22(6):492-8. doi: 10.1038/nsmb.3015. Epub 2015 May 4.
9
[AAA proteins as unfoldases].[作为解折叠酶的AAA蛋白]
Tanpakushitsu Kakusan Koso. 2004 May;49(7 Suppl):1044-6.
10
Substrate specific consequences of central pore mutations in the i-AAA protease Yme1 on substrate engagement.i-AAA蛋白酶Yme1中中央孔突变对底物结合的底物特异性影响。
J Struct Biol. 2006 Oct;156(1):101-8. doi: 10.1016/j.jsb.2006.01.009. Epub 2006 Feb 21.
本文引用的文献
1
Structures of AAA protein translocase Bcs1 suggest translocation mechanism of a folded protein.AAA 蛋白转运酶 Bcs1 的结构揭示了折叠蛋白的转运机制。
Nat Struct Mol Biol. 2020 Feb;27(2):202-209. doi: 10.1038/s41594-020-0373-0. Epub 2020 Feb 10.
2
Structure of the Bcs1 AAA-ATPase suggests an airlock-like translocation mechanism for folded proteins.Bcs1 AAA-ATPase 的结构提示折叠蛋白的转运机制类似气闸。
Nat Struct Mol Biol. 2020 Feb;27(2):142-149. doi: 10.1038/s41594-019-0364-1. Epub 2020 Jan 27.
3
Substrate processing by the Cdc48 ATPase complex is initiated by ubiquitin unfolding.Cdc48 ATPase 复合物通过展开泛素启动底物加工。
Science. 2019 Aug 2;365(6452). doi: 10.1126/science.aax1033. Epub 2019 Jun 27.
4
Structure of the Cdc48 segregase in the act of unfolding an authentic substrate.Cdc48 解聚酶在展开真实底物时的结构。
Science. 2019 Aug 2;365(6452):502-505. doi: 10.1126/science.aax0486. Epub 2019 Jun 27.
5
Structure of Vps4 with circular peptides and implications for translocation of two polypeptide chains by AAA+ ATPases.Vps4 与环状肽的结构及其对 AAA+ ATPases 转运两条多肽链的影响。
Elife. 2019 Jun 11;8:e44071. doi: 10.7554/eLife.44071.
6
Substrate-engaged 26 proteasome structures reveal mechanisms for ATP-hydrolysis-driven translocation.结合底物的 26 蛋白酶体结构揭示了 ATP 水解驱动转运的机制。
Science. 2018 Nov 30;362(6418). doi: 10.1126/science.aav0725. Epub 2018 Oct 11.
7
Structure of the mitochondrial inner membrane AAA+ protease YME1 gives insight into substrate processing.线粒体内膜AAA+蛋白酶YME1的结构有助于深入了解底物加工过程。
Science. 2017 Nov 3;358(6363). doi: 10.1126/science.aao0464.
8
Ratchet-like polypeptide translocation mechanism of the AAA+ disaggregase Hsp104.AAA+解聚酶Hsp104的棘轮状多肽转运机制
Science. 2017 Jul 21;357(6348):273-279. doi: 10.1126/science.aan1052. Epub 2017 Jun 15.
9
Molecular Mechanism of Substrate Processing by the Cdc48 ATPase Complex.Cdc48 ATP酶复合体进行底物加工的分子机制
Cell. 2017 May 4;169(4):722-735.e9. doi: 10.1016/j.cell.2017.04.020.
10
Structure of a AAA+ unfoldase in the process of unfolding substrate.AAA+解折叠酶在展开底物过程中的结构
Elife. 2017 Apr 8;6:e25754. doi: 10.7554/eLife.25754.
Zotero 插件