胸腔积液作为隐匿性多发性骨髓瘤的首个髓外临床表现：内科胸腔镜的作用

Pleural effusion as first extra-medullary clinical presentation of an occult multiple myeloma: The role of medical thoracoscopy.

作者信息

Coppola Antonietta, Ghinassi Giacomo, Ciarleglio Giuseppina, Maccari Uberto, Salerno Laura, Torricelli Elena, Granese Valentina, Valentini Maria Lucia, Zamparelli Alessandro Sanduzzi, Torre Valerio, Scala Raffaele

机构信息

Respiratory Unit, Federico II University, Naples, Italy.

Pulmonology and RICU, S Donato Hospital, Arezzo, Italy.

出版信息

Respir Med Case Rep. 2020 Feb 2;29:101013. doi: 10.1016/j.rmcr.2020.101013. eCollection 2020.

DOI:10.1016/j.rmcr.2020.101013

PMID:32071852

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7013170/

Abstract

Multiple myeloma is a malignant neoplasm of plasma cells that usually invades the bone marrow replacing normal bone marrow and producing large amounts of light chains of immunoglobulins (Ig) [1]. Clinical manifestations are related to the accumulation of these proteins in vital organs such as kidney and heart. Pleural effusion may be a sign of chest involvement that occurs in approximately 6% of patients with Known multiple myeloma [2,3]. We present the case of an 80-year- old man with pleural effusion as first extra-medullary clinical presentation of an occult multiple myeloma.

摘要

多发性骨髓瘤是一种浆细胞恶性肿瘤，通常侵犯骨髓，取代正常骨髓，并产生大量免疫球蛋白（Ig）轻链[1]。临床表现与这些蛋白质在肾脏和心脏等重要器官中的蓄积有关。胸腔积液可能是胸部受累的征象，在已知的多发性骨髓瘤患者中约6%会出现[2,3]。我们报告一例80岁男性患者，以胸腔积液作为隐匿性多发性骨髓瘤的首发髓外临床表现。