Suárez Santiago, Aphalo Paula, Rinaldi Gustavo, Quiroga Alejandra, Añón María Cristina
Centro de Investigación y Desarrollo en Criotecnología de Alimentos (CIDCA-CONICET-CIC-UNLP), Universidad Nacional de La Plata, La Plata, 1900, Argentina.
Facultad de Ciencias Médicas, Universidad Nacional de La Plata, La Plata, 1900, Argentina.
Data Brief. 2020 Jan 23;29:105168. doi: 10.1016/j.dib.2020.105168. eCollection 2020 Apr.
Data set presented in this article is related to the research paper entitled "Effect of amaranth proteins on the RAS system. and assays", available in Food Chemistry [1]. In this article, we evaluated the effect on systolic blood pressure of spontaneously hypertensive rats (SHR) of different samples with amaranth proteins/peptides. The effect of these samples on RAS system was evaluated using and assays. The concentration of renin and angiotensin converting enzyme (ACE) was evaluated using two commercial ELISA kits. Renin concentration was estimated through a direct immunoassay and ACE concentration with an immunoassay based on a competitive inhibition. In addition, the ACE inhibitory activity in plasma was evaluated using a spectrophotometric assay according to [2]. experiments were done with thoracic aorta extracted during the surgical procedure employed to obtain blood samples according to [3]. Data presented in this article recollect a very extensive work on how can be affect the RAS system in SHR model using amaranth protein/peptides as potential antihypertensive samples. These data could be useful to design novel functional foods for hypertensive individuals.
本文中呈现的数据集与发表在《食品化学》[1]上的题为“苋属植物蛋白对肾素-血管紧张素系统的影响及检测”的研究论文相关。在本文中，我们评估了含有苋属植物蛋白/肽的不同样品对自发性高血压大鼠（SHR）收缩压的影响。使用[具体检测方法]检测这些样品对肾素-血管紧张素系统的影响。肾素和血管紧张素转换酶（ACE）的浓度使用两种商用酶联免疫吸附测定（ELISA）试剂盒进行评估。肾素浓度通过直接免疫测定法估算，ACE浓度通过基于竞争性抑制的免疫测定法估算。此外，根据[2]使用分光光度法检测血浆中的ACE抑制活性。[具体实验]是在按照[3]所述获取血样的手术过程中提取胸主动脉进行的。本文中呈现的数据收集了关于使用苋属植物蛋白/肽作为潜在抗高血压样品如何影响SHR模型中肾素-血管紧张素系统的非常广泛的研究工作。这些数据可能有助于为高血压个体设计新型功能性食品。
