Gremlin 对 Notch 信号的分子调控。

Molecular Regulation of Notch Signaling by Gremlin.

机构信息

Cellular and Molecular Biology in Renal and Vascular Pathology, IIS-Fundación Jiménez Díaz, Universidad Autónoma de Madrid, Madrid, Spain.

Red de Investigación Renal (REDINREN), Madrid, Spain.

出版信息

Adv Exp Med Biol. 2020;1227:81-94. doi: 10.1007/978-3-030-36422-9_6.

DOI:10.1007/978-3-030-36422-9_6

PMID:32072500

Abstract

Gremlin is a member of the TGF-β superfamily that can act as a BMP antagonist, and recently, has been described as a ligand of the vascular endothelial growth factor receptor 2 (VEGFR2). Gremlin shares properties with the Notch signaling pathway. Both participate in embryonic development and are reactivated in pathological conditions. Gremlin is emerging as a potential therapeutic target and biomarker of renal diseases. Here we review the role of the Gremlin-VEGFR2 axis in renal damage and downstream signaling mechanisms, such as Notch pathway.

摘要

Gremlin 是 TGF-β 超家族的成员，可作为 BMP 拮抗剂，最近被描述为血管内皮生长因子受体 2 (VEGFR2) 的配体。Gremlin 与 Notch 信号通路具有共同特性。两者都参与胚胎发育，并在病理条件下被重新激活。Gremlin 正成为肾脏疾病的潜在治疗靶点和生物标志物。本文综述了 Gremlin-VEGFR2 轴在肾脏损伤及下游信号通路（如 Notch 通路）中的作用。