Department of Chemical Engineering, Graduate School of Engineering, Kyushu University, 744 Motooka Nishi-ku, Fukuoka 819-0395, Japan.
J Mater Chem B. 2020 Mar 11;8(10):2010-2019. doi: 10.1039/c9tb02418b.
Controlled polymerization through living radical polymerization is widely studied. Controlled polymerization enables synthetic polymers with precise structures, which have the potential for excellent bio-functional materials. This review summarizes the applications of controlled polymers, especially those via living radical polymerization, to biofunctional materials and conjugation with biomolecules. In the case of polymer ligands like glycopolymers, the polymers control the interactions with proteins and cells based on the precise polymer structures. Living radical polymerization enables the conjugation of polymers to proteins, antibodies, nucleic acids and cells. Those polymer conjugations are a sophisticated method to modify bio-organisms. The polymer conjugations expand the potential of biofunctional materials and are useful for understanding biology.
通过活性自由基聚合进行可控聚合得到了广泛的研究。可控聚合使具有精确结构的合成聚合物成为可能，这些聚合物具有成为优秀的生物功能材料的潜力。本综述总结了可控聚合物，特别是通过活性自由基聚合得到的聚合物，在生物功能材料中的应用，以及与生物分子的结合。在聚合物配体（如糖聚合物）的情况下，聚合物基于精确的聚合物结构控制与蛋白质和细胞的相互作用。活性自由基聚合使聚合物与蛋白质、抗体、核酸和细胞的结合成为可能。这些聚合物缀合物是修饰生物有机的一种复杂方法。聚合物缀合物扩展了生物功能材料的潜力，对于理解生物学很有用。
