手性 N,N'-二氧化物-铁（III）催化的不对称过氧化物磺氧化反应。
Chiral N,N'-dioxide-iron(iii)-catalyzed asymmetric sulfoxidation with hydrogen peroxide.
机构信息
Key Laboratory of Green Chemistry & Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064, P. R. China.
出版信息
Chem Commun (Camb). 2020 Mar 12;56(21):3233-3236. doi: 10.1039/d0cc00434k.
PMID:32073076
Abstract
A highly enantioselective sulfoxidation of various sulfides has been achieved by a N,N'-dioxide-iron(iii) complex with 35% aq. H2O2 as the oxidant. The utility of the current method was demonstrated by asymmetric gram-scale synthesis of drug molecule (R)-modafinil. Moreover, a possible working mode was provided to elucidate the chiral induction.
摘要
一种 N,N'-二氧化物-铁（III）配合物与 35%的水过氧化氢作为氧化剂，实现了各种硫醚的高对映选择性氧化。该方法的实用性通过药物分子（R）-莫达非尼的不对称克级合成得到了证明。此外，还提供了一种可能的作用模式来阐明手性诱导。
Zotero 插件