手性铁（II）配合物催化的烷基乙烯基醚对映选择性[1,3]氧到碳的重排反应以及色满醇及其衍生物的合成
Chiral Fe(ii) complex catalyzed enantioselective [1,3] O-to-C rearrangement of alkyl vinyl ethers and synthesis of chromanols and beyond.
作者信息
Wang Lifeng, Zhou Pengfei, Lin Qianchi, Dong Shunxi, Liu Xiaohua, Feng Xiaoming
机构信息
Key Laboratory of Green Chemistry & Technology, Ministry of Education, College of Chemistry, Sichuan University Chengdu 610064 China
出版信息
Chem Sci. 2020 Sep 7;11(37):10101-10106. doi: 10.1039/d0sc04340k.
A highly efficient enantioselective [1,3] O-to-C rearrangement of racemic vinyl ethers that operates under mild conditions was developed. This method with chiral ferrous complex catalyst provided an efficient access to a wide range of chromanols with high yields and excellent enantioselectivities. In addition, an important urological drug ()-tolterodine and others were easily obtained after simple transformations.
开发了一种在温和条件下进行的外消旋乙烯基醚的高效对映选择性[1,3]氧到碳重排反应。这种使用手性亚铁配合物催化剂的方法为高效合成各种具有高收率和优异对映选择性的色满醇提供了一条途径。此外，一种重要的泌尿科药物（）-托特罗定等经过简单转化后很容易得到。
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