Tritschler Tobias, Kraaijpoel Noémie, Langlois Nicole, Girard Philippe, Schulman Sam, Büller Harry R, Segers Annelise, Righini Marc, Le Gal Grégoire
Department of Medicine, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, ON, Canada.
Department of General Internal Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
J Thromb Haemost. 2020 Jun;18(6):1415-1420. doi: 10.1111/jth.14775. Epub 2020 Mar 30.
Pulmonary embolism (PE)-related death is often part of the primary outcome in venous thromboembolism (VTE) studies. The Scientific and Standardization Committee (SSC) of the International Society on Thrombosis and Haemostasis developed a definition for PE-related death and classification of the cause of death. The present survey evaluated a preliminary version of this definition and classification.
Sixty-nine VTE experts from nine countries were invited for a cross-sectional online survey on January 15, 2019, including multiple-choice and open-ended questions on a seven-subcategory classification of the cause of death. Descriptive statistics were used to describe the results; qualitative comments were summarized.
Forty of 69 (58%) invitees completed the survey. All respondents agreed that guidance on classification of the cause of death in VTE studies is required. There was high agreement on the proposal (median overall score, 6; interquartile range, 6-7; scale from 1 [poor] to 7 [excellent]). All respondents approved the wording and content of the seven subcategories, except for one disagreeing vote for two subcategories (A3: "PE is not objectively confirmed, but is most likely the main cause of death" and C1: "Another cause of death is more likely than PE but has not been objectively confirmed"). Suggestions for improvement mainly concerned the extensiveness of the criteria and clinical situations described to define the cause of death.
Acceptance of the proposal was excellent. Suggestions for improvement were incorporated in the SSC communication on the definition of PE-related death and classification of the cause of death in VTE studies.
肺栓塞（PE）相关死亡通常是静脉血栓栓塞症（VTE）研究主要结局的一部分。国际血栓与止血学会科学与标准化委员会（SSC）制定了PE相关死亡的定义及死因分类。本次调查评估了该定义和分类的初稿。
2019年1月15日，邀请了来自9个国家的69名VTE专家参与一项横断面在线调查，包括关于死因七分类的多项选择题和开放式问题。采用描述性统计描述结果；对定性评论进行总结。
69名受邀者中有40名（58%）完成了调查。所有受访者都认为VTE研究中需要死因分类指南。对该提议的认可度很高（总体中位数得分，6；四分位间距，6 - 7；评分范围从1[差]到7[优]）。除了对两个子类别（A3：“PE未得到客观证实，但很可能是主要死因”和C1：“另一个死因比PE更有可能，但未得到客观证实”）有一票反对外，所有受访者都认可七个子类别中的措辞和内容。改进建议主要涉及定义死因所描述的标准和临床情况的广泛性。
对该提议的接受度很高。改进建议已纳入SSC关于VTE研究中PE相关死亡定义和死因分类的通报中。
