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Azidothymidine inhibits mitogen stimulated growth and DNA-repair in human peripheral lymphocytes.

作者信息

Munch-Petersen B

机构信息

Institute of Life Sciences & Chemistry, Roskilde University, Denmark.

出版信息

Biochem Biophys Res Commun. 1988 Dec 30;157(3):1369-75. doi: 10.1016/s0006-291x(88)81026-x.

DOI:10.1016/s0006-291x(88)81026-x
PMID:3207427
Abstract

Until now, 3'-Azido-3'-deoxythymidine (AZT) is the most widely used drug in AIDS therapy, but the positive anti HIV effect of the drug is often accompanied by severe side effects such as bone-marrow suppression. In the present study, the effect of AZT on UV induced DNA strand-break rejoining and on phytohemagglutinin stimulated growth of lymphocytes from 7 healthy volunteers has been examined, and inhibitory effects of the drug was observed at therapeutic concentrations, i.e. 1-10 uM AZT.

摘要

相似文献

1
Azidothymidine inhibits mitogen stimulated growth and DNA-repair in human peripheral lymphocytes.
Biochem Biophys Res Commun. 1988 Dec 30;157(3):1369-75. doi: 10.1016/s0006-291x(88)81026-x.
2
Thymidine in the micromolar range promotes rejoining of UVC-induced DNA strand breaks and prevents azidothymidine from inhibiting the rejoining in quiescent human lymphocytes.微摩尔范围内的胸苷可促进UVC诱导的DNA链断裂的重新连接，并防止叠氮胸苷抑制静止人类淋巴细胞中的重新连接。
Mutat Res. 1997 Mar 12;383(2):143-53. doi: 10.1016/s0921-8777(96)00054-7.
3
3"-Azido-3'-deoxythymidine and 2',3'-dideoxycytidine do not inhibit gene-specific DNA repair in hamster cells.3'-叠氮-3'-脱氧胸苷和2',3'-双脱氧胞苷不抑制仓鼠细胞中的基因特异性DNA修复。
Biochem Biophys Res Commun. 1995 Mar 8;208(1):198-203. doi: 10.1006/bbrc.1995.1323.
4
Effects of 3'-azido-3'-deoxythymidine (AZT) on short-term cultured human peripheral blood lymphocytes.
Eur J Clin Invest. 1989 Apr;19(2):167-71. doi: 10.1111/j.1365-2362.1989.tb00212.x.
5
[UV-induced unscheduled DNA synthesis in differentiated and dedifferentiated lymphocytes from human peripheral blood under the action of DNA-repair and -replication inhibitors].[DNA修复和复制抑制剂作用下人外周血中分化和去分化淋巴细胞的紫外线诱导非定标DNA合成]
Tsitologiia. 1989 Feb;31(2):215-9.
6
Induction and disappearance of DNA strand breaks in human peripheral blood lymphocytes and fibroblasts treated with methyl methanesulfonate.甲磺酸甲酯处理的人外周血淋巴细胞和成纤维细胞中DNA链断裂的诱导与消失
Exp Cell Res. 1991 Jan;192(1):61-6. doi: 10.1016/0014-4827(91)90157-p.
7
Metronidazole induces DNA strand-breaks in cultures of human lymphocytes and phytohemagglutinin-stimulated human lymphocytes.甲硝唑可诱导人淋巴细胞培养物及植物血凝素刺激的人淋巴细胞中的DNA链断裂。
Arzneimittelforschung. 1991 Jan;41(1):65-9.
8
Nature of DNA lesions induced in human hepatoma cells, human colonic cells and human embryonic lung fibroblasts by the antiretroviral drug 3'-azido-3'-deoxythymidine.抗逆转录病毒药物3'-叠氮-3'-脱氧胸苷在人肝癌细胞、人结肠细胞和人胚肺成纤维细胞中诱导产生的DNA损伤的性质。
Mutat Res. 2006 Jan 29;593(1-2):97-107. doi: 10.1016/j.mrfmmm.2005.06.029. Epub 2005 Sep 13.
9
[DNA repair in the UV irradiation of human peripheral blood lymphocytes (healthy donors and xeroderma pigmentosum patients) in relation to the dedifferentiation process in phytohemagglutinin exposure].[紫外线照射人外周血淋巴细胞（健康供体和着色性干皮病患者）时的DNA修复与植物血凝素暴露下的去分化过程的关系]
Tsitologiia. 1984 May;26(5):599-604.
10
Individual susceptibility to DNA telomerase inhibitors: a study on the chromosome instability induced by 3'-azido-3'-deoxythymidine in lymphocytes of elderly twins.个体对DNA端粒酶抑制剂的易感性：一项关于3'-叠氮-3'-脱氧胸苷诱导老年双胞胎淋巴细胞染色体不稳定性的研究。
Mutagenesis. 2004 Mar;19(2):99-104. doi: 10.1093/mutage/geh014.

引用本文的文献

1
Evidence that high-dosage zidovudine at time of retrovirus exposure reduces antiviral efficacy.有证据表明，在接触逆转录病毒时使用高剂量齐多夫定会降低抗病毒疗效。
Antimicrob Agents Chemother. 1996 Sep;40(9):2183-6. doi: 10.1128/AAC.40.9.2183.
2
Inhibitory effect of 3'-azido-3'-deoxythymidine on proliferative responsiveness of CD8+ lymphocytes to interleukin-2.3'-叠氮-3'-脱氧胸苷对CD8 +淋巴细胞对白介素-2增殖反应性的抑制作用。
Clin Diagn Lab Immunol. 1994 Jul;1(4):482-5. doi: 10.1128/cdli.1.4.482-485.1994.
3
Anti-human immunodeficiency virus synergism by zidovudine (3'-azidothymidine) and didanosine (dideoxyinosine) contrasts with their additive inhibition of normal human marrow progenitor cells.
齐多夫定（3'-叠氮胸苷）与去羟肌苷（双脱氧肌苷）对人类免疫缺陷病毒具有协同作用，这与其对正常人骨髓祖细胞的相加抑制作用形成对比。
Antimicrob Agents Chemother. 1991 Feb;35(2):322-8. doi: 10.1128/AAC.35.2.322.
4
Nuclear and mitochondrial changes of muscle fibers in AIDS after treatment with high doses of zidovudine.高剂量齐多夫定治疗后艾滋病患者肌纤维的细胞核及线粒体变化
Acta Neuropathol. 1992;85(1):39-47. doi: 10.1007/BF00304632.