Genter E I, Zhestianikov V D, Mikhel'son V M, Prokof'eva V V
Tsitologiia. 1984 May;26(5):599-604.
UV-induced unscheduled DNA synthesis has been studied in lymphocytes of healthy donors and of Xeroderma pigmentosum patients (the classic form, and a form with an increased sensitivity to gamma-ray). In order to study the influence of PHA-induced differentiation on repair capacity of cells, lymphocytes were cultured in the presence or in the absence of PHA. The data obtained show that PHA-induced differentiation of human lymphocytes leads to an increase in the intensity of repair after UV-irradiation of these cells, and, accordingly, the repair is completed in a shorter time. In the case of the classic form of Xeroderma pigmentosum, the effect of differentiation on the repair level is more distinct, but no effect is observed in cells of Xeroderma pigmentosum sensitive both to UV and gamma-ray.
已对健康供体以及色素性干皮病患者（典型形式和对γ射线敏感性增加的一种形式）的淋巴细胞中的紫外线诱导的非定规DNA合成进行了研究。为了研究PHA诱导的分化对细胞修复能力的影响，淋巴细胞在有或没有PHA的情况下进行培养。获得的数据表明，PHA诱导的人淋巴细胞分化导致这些细胞紫外线照射后修复强度增加，因此，修复在更短的时间内完成。在色素性干皮病的典型形式中，分化对修复水平的影响更明显，但在对紫外线和γ射线均敏感的色素性干皮病细胞中未观察到影响。
