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基于标准化摄入评估的酒精依赖患者以患者为中心的安置匹配:一项探索性随机对照试验的主要结果。

Patient-Centered Placement Matching of Alcohol-Dependent Patients Based on a Standardized Intake Assessment: Primary Outcomes of an Exploratory Randomized Controlled Trial.

机构信息

Department of Medical Psychology, Centre for Psychosocial Medicine, University Medical Centre, Hamburg, Germany,

Department of Health Economics and Health Services Research, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany.

出版信息

Eur Addict Res. 2020;26(3):109-121. doi: 10.1159/000505913. Epub 2020 Feb 19.

DOI:10.1159/000505913
PMID:32074597
Abstract

BACKGROUND

Placement matching guidelines are promising means to optimize patient-centered care and to match patients' treatment needs. Despite considerable research regarding placement matching approaches to optimize alcohol abuse treatment, findings are inconclusive.

OBJECTIVES

To investigate whether the use of patient-centered placement matching (PCPM) guidelines is more effective in reducing heavy drinking and costs 6 months after discharge from an inpatient alcohol withdrawal treatment compared to usual referral to aftercare. Secondary aims were to investigate whether age, gender, trial site or level of care (LOC) are moderators of efficacy and whether patients who were actually referred to the recommended LOC had better treatment outcomes compared to patients who were treated under- or overmatched.

METHODS

Design. Exploratory randomized controlled trial with measurements during withdrawal treatment and 6 months after initial assessment.

SETTING

Four German psychiatric clinics offering a 7-21 day inpatient qualified withdrawal program for patients suffering from alcohol dependence.

PARTICIPANTS

From 1,927 patients who had a primary diagnosis of alcohol dependence and did not have organized aftercare when entering withdrawal treatment, 299 were invited to participate. Of those, 250 were randomized to the intervention group (IG, n = 123) or the control group (CG, n = 127).

INTERVENTION

The PCPM were applied to patients of the IG by feeding back a recommendation to a LOC for aftercare that was calculated from the Measurements in the Addictions for Triage and Evaluation (MATE) and discussed with the staff of the treatment unit. Patients of the CG received a general feedback regarding their MATE interview on request.

MEASUREMENTS

The MATE, the Client Socio-Demographic and Service Receipt Inventory--European Version and the MATE-Outcomes were administered. Data were analyzed using generalized linear models.

RESULTS

In the intention-to-treat analysis, there were no significant differences between IG and CG regarding days of heavy drinking (incident risk ratio [IRR] 1.09; p = 0.640), direct (IRR 1.06; p = 0.779), indirect (IRR 0.77; p = 0.392) and total costs (IRR 0.89; p = 0.496). Furthermore, none of the investigated moderator variables affected statistically significant drinking or cost-related primary outcomes. Regardless of group allocation, patients who received matched aftercare reported significantly fewer days of heavy drinking than undermatched patients (IRR 2.09; p = 0.004). For patients who were overmatched, direct costs were significantly higher (IRR 1.79; p = 0.024), but with no additional effects on alcohol consumption compared to matched patients.

CONCLUSIONS

While the use of PCPM failed to affect the actual referral to aftercare, our findings suggest that treating patients on the recommended LOC may have the potential to reduce days of heavy drinking compared to undertreatment and costs compared to overtreatment.

摘要

背景

安置匹配指南是优化以患者为中心的护理和匹配患者治疗需求的有前途的方法。尽管针对优化酒精滥用治疗的安置匹配方法进行了大量研究,但结果尚无定论。

目的

调查在从住院酒精戒断治疗出院后 6 个月时,使用以患者为中心的安置匹配(PCPM)指南是否比常规转介至后续护理更能有效减少重度饮酒和降低成本。次要目的是调查年龄、性别、试验地点或护理水平(LOC)是否为疗效的调节剂,以及实际转介至推荐 LOC 的患者是否比治疗不足或过度匹配的患者有更好的治疗结果。

方法

设计。具有在戒断治疗期间和初始评估后 6 个月进行测量的探索性随机对照试验。

设置

四家德国精神病诊所提供为期 7-21 天的住院资格酒精戒断计划,为患有酒精依赖的患者提供服务。

参与者

从 1927 名原发性诊断为酒精依赖且进入戒断治疗时没有组织好后续护理的患者中,邀请了 299 名患者参加。其中,250 名被随机分配到干预组(IG,n=123)或对照组(CG,n=127)。

干预

通过向治疗单位的工作人员反馈根据测量成瘾用于分诊和评估(MATE)计算的后续护理 LOC 的建议,将 PCPM 应用于 IG 的患者。CG 的患者可以根据要求对他们的 MATE 访谈进行一般反馈。

测量

使用测量成瘾用于分诊和评估(MATE)、客户社会人口统计学和服务接受情况清单-欧洲版本和 MATE 结果进行测量。使用广义线性模型进行数据分析。

结果

在意向治疗分析中,IG 和 CG 之间在重度饮酒天数(事件风险比 [IRR]1.09;p=0.640)、直接(IRR1.06;p=0.779)、间接(IRR0.77;p=0.392)和总费用(IRR0.89;p=0.496)方面没有显著差异。此外,没有调查到的调节变量对有统计学意义的饮酒或成本相关的主要结果有影响。无论分组如何,接受匹配后续护理的患者报告的重度饮酒天数明显少于不匹配的患者(IRR2.09;p=0.004)。对于匹配过度的患者,直接费用显著更高(IRR1.79;p=0.024),但与匹配患者相比,对饮酒量没有额外影响。

结论

虽然使用 PCPM 未能影响实际的后续护理转介,但我们的研究结果表明,与治疗不足相比,在推荐的 LOC 上治疗患者可能具有减少重度饮酒天数和降低成本的潜力,与治疗过度相比。

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