Bohle A, Biwer E, Christensen J A
Institute of Pathology, University of Tübingen, FRG.
Blood Purif. 1988;6(4):258-63. doi: 10.1159/000169552.
In various forms of glomerulonephritis, diabetic glomerulosclerosis and decompensated benign nephrosclerosis hyperperfusion injury of the glomeruli may be found in addition to the basic disease in patients with malignant hypertension. The changes consist of adhesions, subendothelial capillary hyalinosis and fat droplets in the hyalin material and in endothelial cells. They occur far more often in males than in females. The highest frequency of hyperperfusion injury was found in patients with membranoproliferative glomerulonephritis type I. The lowest frequency was found with membranous glomerulonephritis. The juxtamedullary part of the kidney, which is not autoregulated, is earlier and more severely affected than the subcapsular part. Hyperperfusion changes occur in the middle and eventually in the subcapsular part of the cortex only when the glomeruli in the juxtamedullar cortex are sclerotic.
在各种形式的肾小球肾炎、糖尿病肾小球硬化症和失代偿性良性肾硬化症中，除了恶性高血压患者的基础疾病外，还可能发现肾小球的高灌注损伤。这些变化包括粘连、内皮下毛细血管玻璃样变以及玻璃样物质和内皮细胞中的脂肪滴。它们在男性中出现的频率远高于女性。I型膜增生性肾小球肾炎患者中高灌注损伤的频率最高。膜性肾小球肾炎患者的频率最低。肾脏的近髓部分不受自身调节，比肾包膜下部分更早、更严重地受到影响。仅当近髓皮质的肾小球发生硬化时，皮质中部才会出现高灌注变化，最终肾包膜下部分也会出现。
