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[程氏长颈鹿重建术用于食管胃交界腺癌近端胃切除术后的初步疗效分析]

[Preliminary efficacy analysis of Cheng's Giraffe reconstruction after proximal gastrectomy in adenocarcinoma of esophagogastric junction].

作者信息

Cheng X D, Xu Z Y, Du Y A, Hu C, Yu J F, Yang L T, Huang L, Yu P F, Dai G G, Zhang Y Q

机构信息

Department of Abdominal Surgery, Zhejiang Cancer Hospital, Hangzhou 310022, China.

Department of Gastrointestinal Surgery, The First Affiliated Hospital, Zhejiang University of Traditional Chinese Medicine, Hangzhou 310006, China.

出版信息

Zhonghua Wei Chang Wai Ke Za Zhi. 2020 Feb 25;23(2):158-162. doi: 10.3760/cma.j.issn.1671-0274.2020.02.011.

Abstract

To investigate the safety and feasibility of proximal partial gastrectomy with Cheng's Giraffe esophagogastric reconstruction for the treatment of early Siewert II adenocarcinoma of esophagogastric junction (AEG). Indication of Cheng's Giraffe esophagogastric reconstruction: (1) Siewert II AEG or Siewert III AEG with diameter < 4 cm; (2) preoperative staging as cT1-2N0M0. A descriptive case series study was carried out. Clinical data of 34 patients with Siewert II AEG undergoing proximal partial gastrectomy and Cheng's Giraffe esophagogastric reconstruction at Department of Abdominal Surgery of Zhejiang Cancer Hospital and Department of Gastrointestinal Surgery, The First Affiliated Hospital of Zhejiang University of Traditional Chinese Medicine from February to July 2018 were retrospectively collected and analyzed, including 14 cases in IA stage, 11 cases in IIA stage and 8 cases in IIB stage. Brief procedure of Cheng's Giraffe esophagogastric reconstruction was as follows: Firstly, 12 cm long tubular stomach was formed by longitudinal incision 4 cm away from the great curvature of the stomach. Secondly, the gastric fundus and His angle were formed. Finally, the distance from His angle to esophagal-tubular gastric anastomosis should be more than 5 cm. The reflux disease questionare (RDQ) scores, radionuclide gastric emptying scintigraphy, and 24-hour multichannel intraluminal (MII)-pH monitoring technology were used to evaluate postoperative gastric emptying and gastroesophageal reflux. All 34 patients successfully completed proximal partial gastrectomy with Cheng's Giraffe esophagogastric reconstruction, including 13 cases by open surgery and 21 cases by laparoscopic surgery. The operation time was (144.6±39.8) minutes, the blood loss during operation was (35.4±17.2) ml. No laparoscopic case was converted to open surgery and no postoperative complication was observed. The postoperative hospital stay was (8.4±2.5) days. The postoperative RDQ score was 4.4±3.1 one month after operation, and 3.3±2.5 six months after operation. Gastric-half emptying time was (67.0±21.5) minutes, and the residual ratio was (52.2±7.7)% in 1 hour, (36.4±3.1)% in 2 hours and (28.8±3.6)% in 3 hours at postoperative 1-month. The 24-hour MII-pH monitoring at postoperative 2-month revealed the frequency of acid reflux was (12.6±7.9) times, frequency of non-acid reflux was (19.6±9.7) times, DeMeester score was 5.8±2.9. Cheng's Giraffe esophagogastric reconstruction is safe and feasible in the treatment of Siewert type II AEG, and has good dynamic and anti-reflux effects.

摘要

探讨采用郑氏长颈鹿食管胃重建术行近端胃部分切除术治疗早期食管胃交界部(AEG)SiewertⅡ型腺癌的安全性及可行性。郑氏长颈鹿食管胃重建术的适应证:(1)SiewertⅡ型AEG或直径<4 cm的SiewertⅢ型AEG;(2)术前分期为cT1-2N0M0。开展一项描述性病例系列研究。回顾性收集并分析2018年2月至7月在浙江省肿瘤医院腹部外科及浙江中医药大学附属第一医院胃肠外科行近端胃部分切除术及郑氏长颈鹿食管胃重建术的34例SiewertⅡ型AEG患者的临床资料,其中ⅠA期14例,ⅡA期11例,ⅡB期8例。郑氏长颈鹿食管胃重建术的简要步骤如下:首先,距胃大弯4 cm处纵行切开形成12 cm长的管状胃。其次,形成胃底和His角。最后,His角至食管-管状胃吻合口的距离应大于5 cm。采用反流疾病问卷(RDQ)评分、放射性核素胃排空闪烁显像及24小时多通道腔内(MII)-pH监测技术评估术后胃排空及胃食管反流情况。34例患者均成功完成近端胃部分切除术及郑氏长颈鹿食管胃重建术,其中开放手术13例,腹腔镜手术21例。手术时间为(144.6±39.8)分钟,术中出血量为(35.4±17.2)ml。无腹腔镜手术中转开放手术情况,未观察到术后并发症。术后住院时间为(8.4±2.5)天。术后1个月RDQ评分为4.4±3.1,术后6个月为3.3±2.5。术后1个月胃半排空时间为(67.0±21.5)分钟,1小时残留率为(52.2±7.7)%,2小时为(36.4±3.1)%,3小时为(28.8±3.6)%。术后2个月24小时MII-pH监测显示酸反流次数为(12.6±7.9)次,非酸反流次数为(19.6±9.7)次,DeMeester评分为5.8±2.9。郑氏长颈鹿食管胃重建术治疗SiewertⅡ型AEG安全可行,且具有良好的动力学及抗反流效果。

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