Zhang Shun, Hu Ren-Hao, Cui Xi-Mao, Song Chun, Jiang Xiao-Hua
Department of Gastrointestinal Surgery, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai 200120, China.
World J Gastrointest Oncol. 2024 Nov 15;16(11):4369-4382. doi: 10.4251/wjgo.v16.i11.4369.
Gastric cancer (GC) is the leading diagnosed malignancy worldwide, especially in China. Radical surgery is the cornerstone of GC treatment. We reviewed previous clinical trials and aimed to provide an update on the factors related to the surgical treatment of GC. The number of registered clinical trials in the field of GC surgery is rapidly increasing. With the development and popularization of endoscopic, laparoscopic, and robotic techniques, GC surgery has gradually entered a new era of precise minimally invasive surgery. Postoperative quality of life has become a major issue in addition to surgical oncological safety. Although great progress has been made in clinical research on GC in China, there are still deficiencies. Many studies enrolled large numbers of patients, but the research data were not of high quality. The characteristics of GC in China include a high incidence, large population, and large proportion of patients with advanced GC, which provides sufficient reason for studying this disease. There is still a need for well-designed, large, randomized clinical trials to improve our knowledge of the surgical treatment of GC.
胃癌（GC）是全球诊断出的主要恶性肿瘤，在中国尤为如此。根治性手术是胃癌治疗的基石。我们回顾了以往的临床试验，旨在提供有关胃癌手术治疗相关因素的最新情况。胃癌手术领域注册的临床试验数量正在迅速增加。随着内镜、腹腔镜和机器人技术的发展与普及，胃癌手术已逐渐进入精准微创手术的新时代。除了手术肿瘤学安全性外，术后生活质量已成为一个主要问题。尽管中国在胃癌临床研究方面取得了很大进展，但仍存在不足。许多研究纳入了大量患者，但研究数据质量不高。中国胃癌的特点包括发病率高、人口基数大以及晚期胃癌患者比例高，这为研究这种疾病提供了充分的理由。仍需要设计良好、大规模的随机临床试验来提高我们对胃癌手术治疗的认识。
