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用于骨组织诊疗的β-磷酸三钙（V）表面自组装聚（L-丙交酯）的制备与表征

Preparation and Characterization of Self-Assembled Poly(l-Lactide) on the Surface of β-Tricalcium Diphosphate(V) for Bone Tissue Theranostics.

作者信息

Zienkiewicz Jan A, Strzep Adam, Jedrzkiewicz Dawid, Nowak Nicole, Rewak-Soroczynska Justyna, Watras Adam, Ejfler Jolanta, Wiglusz Rafal J

机构信息

Institute of Low Temperature and Structure Research, Polish Academy of Sciences, Okolna 2 str., 50-422 Wroclaw, Poland.

Department of Chemistry, University of Wroclaw, F. Joliot-Curie 14 str., 50-383 Wroclaw, Poland.

出版信息

Nanomaterials (Basel). 2020 Feb 15;10(2):331. doi: 10.3390/nano10020331.

DOI:10.3390/nano10020331
PMID:32075235
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7075192/
Abstract

This work was aimed to obtain and characterize the well-defined biocomposites based on β-tricalcium diphosphate(V) (β-TCP) co-doped with Ce and Pr ions modified by poly(l-lactide) (PLLA) with precise tailored chain length and different phosphate to polymer ratio. The composites as well as β-tricalcium diphosphate(V) were spectroscopically characterized using emission spectroscopy and luminescence kinetics. Morphological and structural properties were studied using X-Ray Diffraction (XRD) and Scanning Electron Microscopy (SEM). The self-assembled poly(l-lactide) in a shape of rose flower has been successfully polymerized on the surface of the β-tricalcium diphosphate(V) nanocrystals. The studied materials were evaluated in vitro including cytotoxicity (MTT assay) and hemolysis tests. The obtained results suggested that the studied materials may find potential application in tissue engineering.

摘要

这项工作旨在获得并表征基于β-磷酸三钙（V）（β-TCP）的明确生物复合材料，该材料共掺杂有铈和镨离子，并由具有精确定制链长和不同磷酸盐与聚合物比例的聚（L-丙交酯）（PLLA）改性。使用发射光谱和发光动力学对复合材料以及β-磷酸三钙（V）进行光谱表征。使用X射线衍射（XRD）和扫描电子显微镜（SEM）研究形态和结构性质。呈玫瑰花形状的自组装聚（L-丙交酯）已成功聚合在β-磷酸三钙（V）纳米晶体表面。对所研究的材料进行了体外评估，包括细胞毒性（MTT试验）和溶血试验。所得结果表明，所研究的材料可能在组织工程中找到潜在应用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d26e/7075192/ae305a65d909/nanomaterials-10-00331-g008.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d26e/7075192/a4ed16319521/nanomaterials-10-00331-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d26e/7075192/58bd9681a9f4/nanomaterials-10-00331-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d26e/7075192/856ef1a9894a/nanomaterials-10-00331-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d26e/7075192/ae305a65d909/nanomaterials-10-00331-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d26e/7075192/5dfe69be2729/nanomaterials-10-00331-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d26e/7075192/c25cc8811db1/nanomaterials-10-00331-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d26e/7075192/1312fcc8f9dd/nanomaterials-10-00331-g003.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d26e/7075192/a4ed16319521/nanomaterials-10-00331-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d26e/7075192/58bd9681a9f4/nanomaterials-10-00331-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d26e/7075192/856ef1a9894a/nanomaterials-10-00331-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d26e/7075192/ae305a65d909/nanomaterials-10-00331-g008.jpg

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