Parsloe M, Chater S N, Bembridge M, Simpson K H
University Department of Anaesthesia, St James's University Hospital, Leeds.
Br J Anaesth. 1988 Dec;61(6):702-6. doi: 10.1093/bja/61.6.702.
Pain, analgesic requirements, mouth opening and emesis were assessed in 60 patients who received either piroxicam 40 mg or placebo before dental surgery under general anaesthesia which included breathing either halothane or isoflurane. Patients went home on the day after surgery and completed a questionnaire concerning pain and emesis. There were four groups of 15 subjects: piroxicam-halothane, piroxicam-isoflurane, placebo-halothane or placebo-isoflurane. Pain increased at 2 and 4 h and had reduced by 18 h after surgery; there were no significant differences between the groups in pain scores. After operation, fewer patients in the piroxicam-isoflurane group required papaveretum compared with the piroxicam-halothane and placebo-halothane groups. Mouth opening was reduced between 2 and 4 h after surgery, but was less restricted after piroxicam-isoflurane than placebo-halothane. There was no difference between the groups in the incidence of emesis within 18 h of surgery. The postal questionnaire suggested that pain and emesis were reduced significantly during the 3 days after surgery in patients who had received piroxicam before surgery, compared with those who had received placebo.
在60例接受全身麻醉下牙科手术的患者中评估疼痛、镇痛需求、张口度和呕吐情况，这些患者在手术前接受了40毫克吡罗昔康或安慰剂，全身麻醉包括吸入氟烷或异氟烷。患者术后当天回家，并完成了一份关于疼痛和呕吐的问卷。共有四组，每组15名受试者：吡罗昔康 - 氟烷组、吡罗昔康 - 异氟烷组、安慰剂 - 氟烷组或安慰剂 - 异氟烷组。术后2小时和4小时疼痛加剧，术后18小时疼痛减轻；各组疼痛评分之间无显著差异。术后，与吡罗昔康 - 氟烷组和安慰剂 - 氟烷组相比，吡罗昔康 - 异氟烷组需要使用吗啡的患者较少。术后2至4小时张口度减小，但吡罗昔康 - 异氟烷组比安慰剂 - 氟烷组受限程度小。术后18小时内各组呕吐发生率无差异。邮寄问卷调查表明，与接受安慰剂的患者相比，术前接受吡罗昔康的患者术后3天内疼痛和呕吐明显减轻。
