N. I. Pirogov Russian National Research Medical University of the Ministry of Health of Russia, Moscow, Russia.
State Budgetary Healthcare Establishment Center for Family Planning and Reproduction of Moscow Healthcare Department, Moscow, Russia.
J Matern Fetal Neonatal Med. 2022 Feb;35(3):541-545. doi: 10.1080/14767058.2020.1728738. Epub 2020 Feb 19.
To evaluate the combined identification of placental alpha-1 microglobulin (PAMG-1) in cervicovaginal secretions and ultrasound cervical length measurement in pregnant women with symptoms of threatening premature bith (PB) and intact fetal membranes to predict the time of labor onset.
A prospective observational study including 137 pregnant women at a gestational age of 22-37 weeks with symptoms of PB. Presence of PAMG-1 was determined using the commercially available test kit (Parsagen Diagnostics Inc, Boston, USA) and the cervical length was measured using ultrasound.
Ultrasound cervicometry in women with the cervical length between 15 and 30 mm had a positive predictive value of only 8.9% for PB within 7 and 14 days. The test in women with the cervical length between 15 and 30 mm had the positive predictive value for PB within 7 and 14 days of 63.6%.
Using the combination of ultrasound cervicometry and PAMG-1 testing in women with symptoms of PB and the cervical length between 15 and 30 mm may allow to identify those with a high risk of PB within 7 and 14 days more accurately.
评估宫颈阴道分泌物中胎盘α-1 微球蛋白（PAMG-1）与超声宫颈长度测量联合用于有早产先兆（PB）和胎膜完整的孕妇，以预测分娩时间。
这是一项前瞻性观察研究，共纳入 137 名妊娠 22-37 周、有 PB 症状的孕妇。使用市售的测试试剂盒（Parsagen Diagnostics Inc，波士顿，美国）检测 PAMG-1 的存在，使用超声测量宫颈长度。
宫颈长度为 15-30mm 的孕妇中，超声宫颈测量法对 7-14 天内 PB 的阳性预测值仅为 8.9%。宫颈长度为 15-30mm 的孕妇中， 测试对 7-14 天内 PB 的阳性预测值为 63.6%。
在有 PB 症状且宫颈长度为 15-30mm 的孕妇中，联合使用超声宫颈测量法和 PAMG-1 检测，可能更准确地识别出 7-14 天内 PB 风险较高的孕妇。
