氯喹进入精液的过程。
Passage of chloroquine into semen.
作者信息
Ette E I, Ogonor J I, Essien E E
机构信息
Department of Clinical Pharmacy and Biopharmacy, School of Pharmacy, College of Medicine, University of Lagos, Idi-Araba, Nigeria.
出版信息
Br J Clin Pharmacol. 1988 Aug;26(2):179-82. doi: 10.1111/j.1365-2125.1988.tb03384.x.
Abstract
The passage of chloroquine into semen was investigated in four healthy men following the oral administration of four chloroquine sulphate tablets (600 mg base) to each subject. Chloroquine was found to be excreted into semen with a slow transfer rate constant of 0.0002 min-1, and the semen/plasma ratio based on regression analysis was 0.40 +/- 0.06 (mean +/- s.d.). It is concluded that the passage of chloroquine from plasma to semen occurs by passive diffusion.
摘要
对四名健康男性进行研究，在他们每人口服四片硫酸氯喹片（600毫克碱基）后，检测氯喹进入精液的情况。结果发现氯喹以0.0002分钟-1的缓慢转运速率常数排泄到精液中，基于回归分析得出的精液/血浆比率为0.40±0.06（平均值±标准差）。得出的结论是，氯喹从血浆进入精液是通过被动扩散实现的。
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