氯喹和脱乙基氯喹在人乳中的排泄情况。
Excretion of chloroquine and desethylchloroquine in human milk.
作者信息
Ogunbona F A, Onyeji C O, Bolaji O O, Torimiro S E
出版信息
Br J Clin Pharmacol. 1987 Apr;23(4):473-6. doi: 10.1111/j.1365-2125.1987.tb03078.x.
Abstract
The excretion of chloroquine and the major metabolite, desethylchloroquine, in breast milk was investigated in eleven lactating mothers following a single oral dose of chloroquine (600 mg base). The average milk to plasma concentration ratio at the 24th hour was 6.6 +/- 2.4 for chloroquine and 1.5 +/- 0.6 for desethylchloroquine in five of the volunteers. In five other volunteers the elimination half-life of chloroquine in milk was 8.8 +/- 4.7 days which was longer than that in saliva (3.9 +/- 1.0 days) from the same volunteers. The maximum daily dose of the drug that the infant can receive from breastfeeding was about 0.7% of the maternal start dose of the drug in malaria chemotherapy. It is, therefore, suggested that it is safe for mothers to breastfeed their infants when undergoing treatment for malaria with chloroquine.
摘要
在11名哺乳期母亲单次口服氯喹（600mg碱基）后，研究了母乳中氯喹及其主要代谢物去乙基氯喹的排泄情况。5名志愿者在第24小时时，氯喹的平均母乳与血浆浓度比为6.6±2.4，去乙基氯喹为1.5±0.6。在另外5名志愿者中，氯喹在母乳中的消除半衰期为8.8±4.7天，长于同一志愿者唾液中的消除半衰期（3.9±1.0天）。婴儿通过母乳喂养所能接受的该药物最大日剂量约为母亲疟疾化疗起始剂量的0.7%。因此，建议母亲在用氯喹治疗疟疾时进行母乳喂养是安全的。
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