替阿帕米在母乳中的排泄情况。
Excretion of tiapamil in breast milk.
作者信息
Hartmann D, Lunell N O, Friedrich G, Rane A
机构信息
Pharma Clinical Research, F. Hoffmann-La Roche & Co. Ltd, Basle, Switzerland.
出版信息
Br J Clin Pharmacol. 1988 Aug;26(2):183-6. doi: 10.1111/j.1365-2125.1988.tb03385.x.
Abstract
The excretion of tiapamil in breast milk was studied in six lactating mothers (3-7 days post partum) following a single oral 600 mg dose of the drug. The milk/plasma ratio of tiapamil derived from the areas under the plasma and milk concentration-time curves was 0.44 +/- 0.10 mean +/- s.d.). Assuming an intake of 350 ml of milk during a dosing interval of 12 h, the newborn would be exposed at the maximum to 0.053 mg tiapamil. This small amount does not represent a risk for the baby.
摘要
在6名产后3 - 7天的哺乳期母亲单次口服600毫克替帕米后，研究了替帕米在母乳中的排泄情况。根据血浆和乳汁浓度 - 时间曲线下面积得出的替帕米乳汁/血浆比值为0.44±0.10（均值±标准差）。假设在12小时的给药间隔期间摄入350毫升乳汁，新生儿最大暴露量为0.053毫克替帕米。如此少量对婴儿不构成风险。
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本文引用的文献
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Tiapamil, a new calcium antagonist. 2. Further pharmacological characterization and toxicology.
Arzneimittelforschung. 1981;31(9):1401-10.
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Tiapamil, a new calcium antagonist. 1. Demonstration of calcium antagonistic activity and related studies.替帕米，一种新型钙拮抗剂。1. 钙拮抗活性的证明及相关研究。
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Pharmacokinetics and metabolism of tiapamil.硫氮䓬酮的药代动力学与代谢
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J Chromatogr. 1984 Sep 14;310(1):119-27. doi: 10.1016/0378-4347(84)80073-0.
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[Initial experiences with the calcium antagonist tiapamil in the treatment of arterial hypertension].[钙拮抗剂替帕米治疗动脉高血压的初步经验]
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