Department of Immunology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.
Department of Immunology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.
Immunity. 2020 Feb 18;52(2):209-211. doi: 10.1016/j.immuni.2020.01.010.
Fever has beneficial effects on immune responses; however, its impact on T cell polarization is poorly understood. In this issue of Immunity, Wang et al. show that fever acts through a T cell-intrinsic SMAD4-dependent mechanism that selectively drives Th17 cell differentiation and pathogenicity in autoimmunity.
发热对免疫反应有有益的影响；然而，其对 T 细胞极化的影响知之甚少。在本期《免疫》杂志上，Wang 等人表明，发热通过一种 T 细胞内在的 SMAD4 依赖性机制发挥作用，该机制选择性地驱动自身免疫中的 Th17 细胞分化和致病性。
