发热与 Th17 细胞免疫轴：一些 SMAD 喜欢发热。
A Fever-Th17 Cell Immune Axis: Some SMADs Like It Hot.
机构信息
Department of Immunology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.
Department of Immunology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.
出版信息
Immunity. 2020 Feb 18;52(2):209-211. doi: 10.1016/j.immuni.2020.01.010.
PMID:32075722
Abstract
Fever has beneficial effects on immune responses; however, its impact on T cell polarization is poorly understood. In this issue of Immunity, Wang et al. show that fever acts through a T cell-intrinsic SMAD4-dependent mechanism that selectively drives Th17 cell differentiation and pathogenicity in autoimmunity.
摘要
发热对免疫反应有有益的影响；然而，其对 T 细胞极化的影响知之甚少。在本期《免疫》杂志上，Wang 等人表明，发热通过一种 T 细胞内在的 SMAD4 依赖性机制发挥作用，该机制选择性地驱动自身免疫中的 Th17 细胞分化和致病性。
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