Inflammation and Oncology TA, Amgen Inc., 1120 Veterans Boulevard, South San Francisco, CA 94080, USA.
Inflammation and Oncology TA, Amgen Inc., 1120 Veterans Boulevard, South San Francisco, CA 94080, USA.
EBioMedicine. 2017 Nov;25:20-21. doi: 10.1016/j.ebiom.2017.10.031. Epub 2017 Nov 10.
Th17 cells, which express the cytokine IL-17A, and master regulator RORγt, are important in the inflammatory response to fungal and bacterial pathogens, but also have a pathogenic role in many inflammatory disorders. In contrast, regulatory T cells (Treg), expressing the Foxp3 transcription factor, have a suppressive function and can dampen an immune response. The appropriate balance of these distinct effector functions is critical for an effective immune response and autoimmunity can arise if this process goes awry. In this issue, Wang et al. demonstrate a critical role for the transcription factor CREB (cyclic AMP-responsive element binding protein) in regulating the balance between inflammatory Th17 and suppressive Treg cells with implications for autoimmunity.
Th17 细胞表达细胞因子 IL-17A 和主调控因子 RORγt，在真菌和细菌病原体的炎症反应中起着重要作用，但在许多炎症性疾病中也具有致病性。相比之下，表达转录因子 Foxp3 的调节性 T 细胞 (Treg) 具有抑制功能，可以抑制免疫反应。这些不同效应功能的适当平衡对于有效的免疫反应至关重要，如果这一过程出现异常，自身免疫就会发生。在本期杂志中，Wang 等人证明了转录因子 CREB（环磷酸腺苷反应元件结合蛋白）在调节炎症性 Th17 和抑制性 Treg 细胞之间的平衡方面起着关键作用，这对自身免疫有影响。
