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血清可溶性 CD89-IgA 复合物在无免疫抑制剂病史的 IgA 肾病中升高。

Serum Soluble CD89-IgA Complexes Are Elevated in IgA Nephropathy without Immunosuppressant History.

机构信息

Division of Nephrology, Department of Internal Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China.

Department of Immunology, School of Basic Medicine, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100005, China.

出版信息

Dis Markers. 2020 Jan 16;2020:8393075. doi: 10.1155/2020/8393075. eCollection 2020.

DOI:10.1155/2020/8393075
PMID:32076466
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7017530/
Abstract

PURPOSE

CD89 (FcRI), the receptor of IgA, can shed from cells to form complexes with IgA in serum and is supposed to participate in the pathogenesis of IgA nephropathy (IgAN). There are contradictory results on their utility in clinical practice. This study is aimed at investigating whether sCD89-IgA complexes can help in the diagnosis or evaluation of the disease.

METHODS

A sandwich ELISA was established using anti-CD89 as a capture antibody and HRP-conjugated anti-IgA as a detection antibody. This method was used to measure serum levels of sCD89-IgA complexes in IgAN patients without immunosuppressant history and healthy subjects. Correlations between serum levels of sCD89-IgA complexes and disease severity were analyzed.

RESULTS

Serum sCD89-IgA complexes increased with age ( < 0.001). IgAN patients had higher sCD89-IgA complex levels compared with age- and gender-matched normal healthy individuals ( < 0.001). IgAN patients had higher sCD89-IgA complex levels compared with age- and gender-matched normal healthy individuals ( < 0.001). IgAN patients had higher sCD89-IgA complex levels compared with age- and gender-matched normal healthy individuals (.

CONCLUSIONS

Serum sCD89-IgA complexes can guide diagnosis of IgAN in patients without immunosuppressant history, but provide limited help in clinicopathologic prediction.

摘要

目的

CD89（FcRI）是 IgA 的受体，可从细胞上脱落形成与血清中 IgA 的复合物，被认为参与 IgA 肾病（IgAN）的发病机制。其在临床实践中的应用价值存在争议。本研究旨在探讨 sCD89-IgA 复合物是否有助于诊断或评估该疾病。

方法

采用夹心 ELISA 法，以抗-CD89 为捕获抗体，HRP 标记的抗-IgA 为检测抗体。该方法用于测量无免疫抑制剂史的 IgAN 患者和健康对照者血清中 sCD89-IgA 复合物的水平。分析血清 sCD89-IgA 复合物水平与疾病严重程度的相关性。

结果

血清 sCD89-IgA 复合物随年龄增长而增加（<0.001）。IgAN 患者的 sCD89-IgA 复合物水平高于年龄和性别匹配的正常健康对照者（<0.001）。IgAN 患者的 sCD89-IgA 复合物水平高于年龄和性别匹配的正常健康对照者（<0.001）。

结论

血清 sCD89-IgA 复合物可指导无免疫抑制剂史的 IgAN 患者的诊断，但在临床病理预测方面提供的帮助有限。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9097/7017530/30055ce2de9c/DM2020-8393075.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9097/7017530/b377c02aa294/DM2020-8393075.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9097/7017530/88f2d09c42de/DM2020-8393075.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9097/7017530/30055ce2de9c/DM2020-8393075.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9097/7017530/b377c02aa294/DM2020-8393075.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9097/7017530/88f2d09c42de/DM2020-8393075.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9097/7017530/30055ce2de9c/DM2020-8393075.003.jpg

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本文引用的文献

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Clin Chem Lab Med. 2017 Nov 27;56(1):75-85. doi: 10.1515/cclm-2017-0090.
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Oxford Classification of IgA nephropathy 2016: an update from the IgA Nephropathy Classification Working Group.
IgA 肾病在世界不同地区是同一种疾病吗？
Semin Immunopathol. 2021 Oct;43(5):707-715. doi: 10.1007/s00281-021-00884-7. Epub 2021 Aug 20.
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IgA vasculitis nephritis in children and adults: one or different entities?儿童与成人 IgA 血管炎肾炎：一种疾病还是两种不同疾病？
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Urinary myeloid IgA Fc alpha receptor (CD89) and transglutaminase-2 as new biomarkers for active IgA nephropathy and henoch-Schönlein purpura nephritis.尿髓样免疫球蛋白A Fcα受体（CD89）和转谷氨酰胺酶-2作为活动性IgA肾病和过敏性紫癜性肾炎的新生物标志物。
BBA Clin. 2016 Feb 17;5:79-84. doi: 10.1016/j.bbacli.2016.02.002. eCollection 2016 Jun.
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Recurrent IgA nephropathy is predicted by altered glycosylated IgA, autoantibodies and soluble CD89 complexes.反复性 IgA 肾病可由糖基化 IgA、自身抗体和可溶性 CD89 复合物改变所预测。
Kidney Int. 2015 Oct;88(4):815-22. doi: 10.1038/ki.2015.158. Epub 2015 Jun 10.
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Transglutaminase is essential for IgA nephropathy development acting through IgA receptors.转谷氨酰胺酶通过 IgA 受体对于 IgA 肾病的发展是必需的。
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