Institute of Biomedical Engineering, National Taiwan University, No. 1, Sec. 4, Roosevelt Rd., Taipei 10617, Taiwan.
Department of Neurosurgery, Mackay Memorial Hospital, No. 92, Sec. 2, Zhongshan N. Rd., Taipei 10449, Taiwan.
J Healthc Eng. 2020 Jan 30;2020:1323270. doi: 10.1155/2020/1323270. eCollection 2020.
Recent years have seen a rapidly rising number of oxygenated water brands that claim to impart health benefits and increase athletic performance by improving oxygen availability in the body. Drinks with higher dissolved oxygen concentrations have in recent times gained popularity as potential ergogenic aids, despite the lack of evidence regarding their efficacy. The aim of this study was to characterize oxygenated water and assess the improvement in uric acid metabolism while identifying performance enhancements in animals administered oxygenated water. Oxygenated water was characterized by hydrogen and oxygen nuclear magnetic resonance (NMR) spectroscopy. Hyperuricemia in rats was induced by treatment with oxonic acid potassium salt, and the animals were given oxygenated drinking water before, during, or after oxonic acid treatment. Serum uric acid was measured to confirm the effects on uric acid metabolism. Following oxygenation, the full width at half maximum (FWHM) was reduced to 11.56 Hz and 64.16 Hz in the hydrogen and oxygen NMR spectra, respectively. Oxygenated water molecule clusters were reduced in size due to the reduction in FWHM. Oxygen concentration did not vary significantly with increased temperature. However, standing time played a critical role in the amount of oxygen dissolved in the water. The rat studies indicated that oxygenated water reduced serum uric acid levels and their rate of increase and enhanced uric acid metabolism. A significant improvement in uric acid metabolism and rate of increase in serum uric acid concentration was observed in hyperuricemic rats administered oxygenated water compared to that in rats administered regular water. High oxygen concentrations enhanced the rate of oxygen absorption, leading to increased glycolysis and mitochondrial protein synthesis. Therefore, oxygenated water is a potential adjuvant therapy or health food for treatment of hyperuricemia.
近年来，声称通过提高体内氧气供应来带来健康益处并提高运动表现的含氧水产品的品牌数量迅速增加。最近，高溶解氧浓度的饮料作为潜在的增强运动表现的辅助剂越来越受欢迎，尽管缺乏关于其疗效的证据。本研究旨在描述含氧水的特性，并评估其在改善尿酸代谢方面的效果，同时确定给予含氧水的动物的性能提升。通过氢和氧核磁共振（NMR）光谱对含氧水进行了特征描述。通过用氧代酸钾盐处理诱导大鼠高尿酸血症，并在氧代酸处理之前、期间或之后给予含氧饮用水。测量血清尿酸以确认对尿酸代谢的影响。氧合后，氢和氧 NMR 光谱中的半峰全宽（FWHM）分别降低至 11.56 Hz 和 64.16 Hz。由于 FWHM 的减小，含氧水分子簇的尺寸减小。氧气浓度随温度升高没有明显变化。然而，静置时间对水中溶解氧的量起着关键作用。大鼠研究表明，含氧水可降低血清尿酸水平及其升高速度，并增强尿酸代谢。与给予常水的大鼠相比，给予含氧水的高尿酸血症大鼠的尿酸代谢和血清尿酸浓度升高速度显著改善。高氧浓度可提高氧吸收速度，从而增加糖酵解和线粒体蛋白合成。因此，含氧水是治疗高尿酸血症的潜在辅助治疗或保健品。
