Demirtas Erdal, Korkmaz İlhan, Cebecioğlu Kıvanç, Ayan Mustafa, Demirtaş Esin, Yurtbay Sefa, Yıldız Şeymanur, Aydın Hüseyin, Szarpak Lukasz
Departments of Emergency Medicine, Sivas Cumhuriyet University Faculty of Medicine, TR-58140 Sivas, Turkey.
Departments of Family Medicine, Sivas Cumhuriyet University Faculty of Medicine, TR-58140 Sivas, Turkey.
Emerg Med Int. 2020 Feb 1;2020:1264714. doi: 10.1155/2020/1264714. eCollection 2020.
The aim of this study was to investigate the serum TLR9 and NF-B levels in patients for the diagnosis and prognostication of AP in the emergency department.
In the current study, we looked at the TLR9 and NF-B levels in patients for the diagnosis and prognostication of AP in the emergency department.
Of the patients with acute pancreatitis, 22 (49%) were male and 23 (51%) were female. The mean age of the patient group was 62 years, with a range of 25-95 years. The control group consisted of 19 (43.1%) male and 25 (56.9%) female patients. The serum TLR9 and NF-B levels in patients for the diagnosis and prognostication of AP in the emergency department. < 0.001 and 8.04 ± 1.76 vs. 4.76 ± 1.13; < 0.001 and 8.04 ± 1.76 vs. 4.76 ± 1.13; B levels in patients for the diagnosis and prognostication of AP in the emergency department. < 0.001 and 8.04 ± 1.76 vs. 4.76 ± 1.13; B levels in patients for the diagnosis and prognostication of AP in the emergency department. < 0.001 and 8.04 ± 1.76 vs. 4.76 ± 1.13.
We demonstrated that the TLR9 and NF-B pathway is activated in acute pancreatitis and increases the inflammatory process. This may help to further understand the pathogenesis of disorder, diagnosis, and clinical severity. We proposed that blockage of these inflammatory pathways may play a role in the prevention of the disease progression and development of inflammatory complications.B levels in patients for the diagnosis and prognostication of AP in the emergency department.
本研究旨在探讨急诊科患者血清中TLR9和NF-κB水平，以用于急性胰腺炎（AP）的诊断和预后评估。
在本研究中，我们观察了急诊科患者用于AP诊断和预后评估的TLR9和NF-κB水平。
急性胰腺炎患者中，22例（49%）为男性，23例（51%）为女性。患者组的平均年龄为62岁，范围为25至95岁。对照组由19例（43.1%）男性和25例（56.9%）女性患者组成。急诊科用于AP诊断和预后评估的患者血清TLR9和NF-κB水平。<0.001，8.04±1.76对比4.76±1.13；<0.001，8.04±1.76对比4.76±1.13；急诊科用于AP诊断和预后评估的患者B水平。<0.001，8.04±1.76对比4.76±1.13；急诊科用于AP诊断和预后评估的患者B水平。<0.001，8.04±1.76对比4.76±1.13。
我们证明了TLR9和NF-κB通路在急性胰腺炎中被激活，并加剧了炎症过程。这可能有助于进一步了解该疾病的发病机制、诊断及临床严重程度。我们提出阻断这些炎症通路可能在预防疾病进展和炎症并发症发生中发挥作用。急诊科用于AP诊断和预后评估的患者B水平。
