Goswami Devalina, Sardar Arijit, Baidya Dalim Kumar, Yadav Rahul, Bhutia Ongkila, Roychoudhury Ajoy
Department of Anaesthesiology, Pain Medicine and Critical Care, All India Institute of Medical Sciences, New Delhi, India.
Department of Oral and Maxillofacial Surgery, All India Institute of Medical Sciences, New Delhi, India.
Turk J Anaesthesiol Reanim. 2020 Feb;48(1):24-30. doi: 10.5152/TJAR.2019.54614. Epub 2019 Sep 24.
This trial investigated the post operative analgesic efficacy of oarl etoricoxib 90 mg and 120 mg and a placebo in mandibular fracture pain model.
A total of 63 adult patients with mandibular fractures who were scheduled to undergo maxillofacial surgery were randomly allocated to receive etoricoxib 90 mg, etoricoxib 120 mg and a placebo 1 hour before the surgery. Patients were followed-up till 24 hours after the surgery. Duration of analgesia, intra-operative and post-operative analgesic requirement, pain score, post-operative patient satisfaction and adverse effects were measured.
The baseline demographic parameters were similar in all the groups. Duration of analgesia was longer in both the E120 (6.00±0.816 hours) and E90 (4.37±1.008 hours) groups (p<0.05) as compared to the placebo group (2.60±0.821 hours). Mean difference of duration of analgesia between E120 and E90 was 1.62 (95% confidence interval: 0.234-3.484; p>0.05). Post-operative pain intensity was significantly lower in both the E120 and E90 groups as compared to the C group. Both the etoricoxib groups required less intra-operative (p=0.002) and post-operative (p=0.001) analgesic supplementation as compared to the placebo group. The patient satisfaction score and rate of occurrence of significant adverse effects were similar among all the three groups.
Etoricoxib 90 mg is equally efficacious to etoricoxib120 mg with a similar side effect profile in a severely acute setting.
本试验研究了90毫克和120毫克口服依托考昔及安慰剂在下颌骨骨折疼痛模型中的术后镇痛效果。
总共63例计划接受颌面外科手术的成年下颌骨骨折患者被随机分配，在手术前1小时接受90毫克依托考昔、120毫克依托考昔和安慰剂。对患者进行随访直至术后24小时。测量镇痛持续时间、术中及术后镇痛需求、疼痛评分、术后患者满意度和不良反应。
所有组的基线人口统计学参数相似。与安慰剂组（2.60±0.821小时）相比，E120组（6.00±0.816小时）和E90组（4.37±1.008小时）的镇痛持续时间更长（p<0.05）。E120组和E90组之间镇痛持续时间的平均差异为1.62（95%置信区间：0.234 - 3.484；p>0.05）。与C组相比，E120组和E90组的术后疼痛强度显著更低。与安慰剂组相比，两个依托考昔组术中（p = 0.002）和术后（p = 0.001）所需的镇痛补充剂更少。三组患者的满意度评分和严重不良反应发生率相似。
在严重急性情况下，90毫克依托考昔与120毫克依托考昔疗效相当，副作用相似。
